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Red Blood Cell Distribution Width Predicts 1-month Complications after Percutaneous Transluminal Angioplasty

BACKGROUND: The identification of patients at higher risk of developing percutaneous transluminal angioplasty (PTA)-related complications is pivotal for achieving better clinical outcomes. We carried out a single-center, observational, retrospective study to explore whether in-hospital changes of re...

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Autores principales: Veraldi, Gian Franco, Mezzetto, Luca, Scorsone, Lorenzo, Macrì, Marco, Simoncini, Fabio, Lippi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708289/
https://www.ncbi.nlm.nih.gov/pubmed/31496911
http://dx.doi.org/10.2478/jomb-2018-0047
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author Veraldi, Gian Franco
Mezzetto, Luca
Scorsone, Lorenzo
Macrì, Marco
Simoncini, Fabio
Lippi, Giuseppe
author_facet Veraldi, Gian Franco
Mezzetto, Luca
Scorsone, Lorenzo
Macrì, Marco
Simoncini, Fabio
Lippi, Giuseppe
author_sort Veraldi, Gian Franco
collection PubMed
description BACKGROUND: The identification of patients at higher risk of developing percutaneous transluminal angioplasty (PTA)-related complications is pivotal for achieving better clinical outcomes. We carried out a single-center, observational, retrospective study to explore whether in-hospital changes of red blood cell distribution width (RDW) may help predicting early development of PTA-related complications. METHODS: The study population consisted of all consecutive patients who underwent PTA for severe peripheral artery occlusive disease (PAOD) during a 2-year period. RDW was measured at hospital admission and discharge, and the delta was calculated. Patient follow-up was routinely performed 1-month after hospital discharge, and was based on thoughtful medical assessment and arterial ultrasonography. The control population consisted of 352 ostensibly healthy subjects. RESULTS: The final PTA group consisted of 224 patients. Hemoglobin was lower, whilst mean corpuscular volume (MCV) and RDW were higher in PAOD cases than in controls. Overall, 11 PAOD patients (4.9%) developed clinically significant PTA-related complications 1-month after hospital discharge. Patients who developed 1-month PTA-related complications had lower hemoglobin concentration, but higher RDW and delta RDW than those who did not. Patients with delta RDW >1 had 60% higher risk of developing 1-month PTA-related complications and 88% higher risk of developing early reocclusion. Overall, RDW exhibited an area under the curve (AUC) of 0.68 and 0.74 for predicting 1-month PTA-related complications and early reocclusion, respectively. CONCLUSIONS: The results of this study suggest that RDW may play a role for guiding the clinical decision making of PTA patients immediately after hospital discharge.
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spelling pubmed-67082892019-09-06 Red Blood Cell Distribution Width Predicts 1-month Complications after Percutaneous Transluminal Angioplasty Veraldi, Gian Franco Mezzetto, Luca Scorsone, Lorenzo Macrì, Marco Simoncini, Fabio Lippi, Giuseppe J Med Biochem Original Paper BACKGROUND: The identification of patients at higher risk of developing percutaneous transluminal angioplasty (PTA)-related complications is pivotal for achieving better clinical outcomes. We carried out a single-center, observational, retrospective study to explore whether in-hospital changes of red blood cell distribution width (RDW) may help predicting early development of PTA-related complications. METHODS: The study population consisted of all consecutive patients who underwent PTA for severe peripheral artery occlusive disease (PAOD) during a 2-year period. RDW was measured at hospital admission and discharge, and the delta was calculated. Patient follow-up was routinely performed 1-month after hospital discharge, and was based on thoughtful medical assessment and arterial ultrasonography. The control population consisted of 352 ostensibly healthy subjects. RESULTS: The final PTA group consisted of 224 patients. Hemoglobin was lower, whilst mean corpuscular volume (MCV) and RDW were higher in PAOD cases than in controls. Overall, 11 PAOD patients (4.9%) developed clinically significant PTA-related complications 1-month after hospital discharge. Patients who developed 1-month PTA-related complications had lower hemoglobin concentration, but higher RDW and delta RDW than those who did not. Patients with delta RDW >1 had 60% higher risk of developing 1-month PTA-related complications and 88% higher risk of developing early reocclusion. Overall, RDW exhibited an area under the curve (AUC) of 0.68 and 0.74 for predicting 1-month PTA-related complications and early reocclusion, respectively. CONCLUSIONS: The results of this study suggest that RDW may play a role for guiding the clinical decision making of PTA patients immediately after hospital discharge. Sciendo 2019-07-30 /pmc/articles/PMC6708289/ /pubmed/31496911 http://dx.doi.org/10.2478/jomb-2018-0047 Text en © 2019 Gian Franco Veraldi, Luca Mezzetto, Lorenzo Scorsone, Marco Macrì, Fabio Simoncini, Giuseppe Lippi, published by Sciendo http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
spellingShingle Original Paper
Veraldi, Gian Franco
Mezzetto, Luca
Scorsone, Lorenzo
Macrì, Marco
Simoncini, Fabio
Lippi, Giuseppe
Red Blood Cell Distribution Width Predicts 1-month Complications after Percutaneous Transluminal Angioplasty
title Red Blood Cell Distribution Width Predicts 1-month Complications after Percutaneous Transluminal Angioplasty
title_full Red Blood Cell Distribution Width Predicts 1-month Complications after Percutaneous Transluminal Angioplasty
title_fullStr Red Blood Cell Distribution Width Predicts 1-month Complications after Percutaneous Transluminal Angioplasty
title_full_unstemmed Red Blood Cell Distribution Width Predicts 1-month Complications after Percutaneous Transluminal Angioplasty
title_short Red Blood Cell Distribution Width Predicts 1-month Complications after Percutaneous Transluminal Angioplasty
title_sort red blood cell distribution width predicts 1-month complications after percutaneous transluminal angioplasty
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708289/
https://www.ncbi.nlm.nih.gov/pubmed/31496911
http://dx.doi.org/10.2478/jomb-2018-0047
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