Cargando…

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes

Tumor necrosis factor receptor 2 (TNFR2) is a transmembrane receptor that is linked to immune modulation and tissue regeneration. Here, we show that TNFR2 essentially promotes long-term pain resolution independently of sex. Genetic deletion of TNFR2 resulted in impaired neuronal regeneration and chr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fischer, Roman, Sendetski, Maksim, del Rivero, Tania, Martinez, George F., Bracchi-Ricard, Valerie, Swanson, Kathryn A., Pruzinsky, Elizabeth K., Delguercio, Niky, Rosalino, Michael J., Padutsch, Tanja, Kontermann, Roland E., Pfizenmaier, Klaus, Bethea, John R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708347/ https://www.ncbi.nlm.nih.gov/pubmed/31391309 http://dx.doi.org/10.1073/pnas.1902091116

Ejemplares similares

Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein
por: Padutsch, Tanja, et al.
Publicado: (2019)

Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis
por: Fiedler, Timon, et al.
Publicado: (2023)

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury
por: Gerald, Marcus J., et al.
Publicado: (2019)

TNFR1/p38αMAPK signaling in Nex+ supraspinal neurons regulates sex-specific chronic neuropathic pain
por: Swanson, Kathryn A., et al.
Publicado: (2023)

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS
por: Pegoretti, Valentina, et al.
Publicado: (2023)

TNFR2: The new Treg switch?
por: Cohen, José L., et al.
Publicado: (2017)

Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis
por: Williams, Sarah K., et al.
Publicado: (2018)

The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation
por: Richter, Fabian, et al.
Publicado: (2021)

The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration
por: Ortí-Casañ, Natalia, et al.
Publicado: (2023)

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach
por: Fischer, Roman, et al.
Publicado: (2020)

Anti-inflammatory treatment in MPN: targeting TNFR1 and TNFR2 in JAK2-V617F–induced disease
por: Müller, Peter, et al.
Publicado: (2021)

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2
por: Fischer, Roman, et al.
Publicado: (2017)

Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation
por: Schmid, Tobias, et al.
Publicado: (2017)

Alterations in Mouse Hypothalamic Adipokine Gene Expression and Leptin Signaling following Chronic Spinal Cord Injury and with Advanced Age
por: Bigford, Gregory E., et al.
Publicado: (2012)

Chronic thoracic spinal cord injury impairs CD8(+) T-cell function by up-regulating programmed cell death-1 expression
por: Zha, Ji, et al.
Publicado: (2014)

Treg activation defect in type 1 diabetes: correction with TNFR2 agonism
por: Okubo, Yoshiaki, et al.
Publicado: (2016)

TARGETING TREG CELLS BY TNFR2 ANTIBODY INDUCES TUMOR REGRESSION IN VIVO
por: Yi, Zuoan David, et al.
Publicado: (2023)

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice
por: Papazian, Irini, et al.
Publicado: (2021)

Aberrant frequency of TNFR2(+) Treg and related cytokines in patients with CIN and cervical cancer
por: Zhang, Teng, et al.
Publicado: (2017)

The role of TNFR2(+) Tregs in COVID-19: An overview and a potential therapeutic strategy
por: Ahmad, Suhana, et al.
Publicado: (2021)

Membrane Tumor Necrosis Factor (TNF) Induced Cooperative Signaling of TNFR60 and TNFR80 Favors Induction of Cell Death Rather Than Virus Production in HIV-infected T Cells
por: Lazdins, Janis K., et al.
Publicado: (1997)

Neuroendocrine and cardiac metabolic dysfunction and NLRP3 inflammasome activation in adipose tissue and pancreas following chronic spinal cord injury in the mouse
por: Bigford, Gregory E., et al.
Publicado: (2013)

The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens
por: Rodriguez-Barbosa, Jose-Ignacio, et al.
Publicado: (2020)

Chronic spinal cord injury attenuates influenza virus-specific antiviral immunity
por: Bracchi-Ricard, Valerie, et al.
Publicado: (2016)

Antibody-Mediated Inhibition of TNFR1 Attenuates Disease in a Mouse Model of Multiple Sclerosis
por: Williams, Sarah K., et al.
Publicado: (2014)

Antitumor Activity of a Mesenchymal Stem Cell Line Stably Secreting a Tumor-Targeted TNF-Related Apoptosis-Inducing Ligand Fusion Protein
por: Marini, Irene, et al.
Publicado: (2017)

A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells
por: He, Xuehui, et al.
Publicado: (2016)

Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury
por: Bigford, Gregory E., et al.
Publicado: (2018)

Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4(+)Foxp3(+) induced Treg cells in vitro and in vivo periphery in autoimmune diseases
por: Yang, Sujuan, et al.
Publicado: (2019)

Inhibition of astroglial nuclear factor κB reduces inflammation and improves functional recovery after spinal cord injury
por: Brambilla, Roberta, et al.
Publicado: (2005)

Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans
por: Fellermeier-Kopf, Sina, et al.
Publicado: (2018)

Combining TNFR2-Expressing Tregs and IL-6 as Superior Diagnostic Biomarkers for High-Grade Serous Ovarian Cancer Masses
por: Kampan, Nirmala Chandralega, et al.
Publicado: (2023)

Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity
por: Richter, Fabian, et al.
Publicado: (2013)

Targeting scFv-Fc-scTRAIL fusion proteins to tumor cells
por: Hutt, Meike, et al.
Publicado: (2018)

Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis
por: Siegmund, Daniela, et al.
Publicado: (2016)

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages
por: Wajant, Harald, et al.
Publicado: (2019)

Fn14 and TNFR2 as regulators of cytotoxic TNFR1 signaling
por: Siegmund, Daniela, et al.
Publicado: (2023)

Inhibition of astroglial NF-kappaB enhances oligodendrogenesis following spinal cord injury
por: Bracchi-Ricard, Valerie, et al.
Publicado: (2013)

Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy
por: Uysal, Husnu, et al.
Publicado: (2018)

Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections
por: Ruiz, Andy, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6sc6li50r39nlofijnmddc508v