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Natural Wolbachia infections are common in the major malaria vectors in Central Africa
During the last decade, the endosymbiont bacterium Wolbachia has emerged as a biological tool for vector disease control. However, for long time, it was believed that Wolbachia was absent in natural populations of Anopheles. The recent discovery that species within the Anopheles gambiae complex host...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708434/ https://www.ncbi.nlm.nih.gov/pubmed/31462916 http://dx.doi.org/10.1111/eva.12804 |
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author | Ayala, Diego Akone‐Ella, Ousman Rahola, Nil Kengne, Pierre Ngangue, Marc F. Mezeme, Fabrice Makanga, Boris K. Nigg, Martha Costantini, Carlo Simard, Frédéric Prugnolle, Franck Roche, Benjamin Duron, Olivier Paupy, Christophe |
author_facet | Ayala, Diego Akone‐Ella, Ousman Rahola, Nil Kengne, Pierre Ngangue, Marc F. Mezeme, Fabrice Makanga, Boris K. Nigg, Martha Costantini, Carlo Simard, Frédéric Prugnolle, Franck Roche, Benjamin Duron, Olivier Paupy, Christophe |
author_sort | Ayala, Diego |
collection | PubMed |
description | During the last decade, the endosymbiont bacterium Wolbachia has emerged as a biological tool for vector disease control. However, for long time, it was believed that Wolbachia was absent in natural populations of Anopheles. The recent discovery that species within the Anopheles gambiae complex host Wolbachia in natural conditions has opened new opportunities for malaria control research in Africa. Here, we investigated the prevalence and diversity of Wolbachia infection in 25 African Anopheles species in Gabon (Central Africa). Our results revealed the presence of Wolbachia in 16 of these species, including the major malaria vectors in this area. The infection prevalence varied greatly among species, confirming that sample size is a key factor to detect the infection. Moreover, our sequencing and phylogenetic analyses showed the important diversity of Wolbachia strains that infect Anopheles. Co‐evolutionary analysis unveiled patterns of Wolbachia transmission within some Anopheles species, suggesting that past independent acquisition events were followed by co‐cladogenesis. The large diversity of Wolbachia strains that infect natural populations of Anopheles offers a promising opportunity to select suitable phenotypes for suppressing Plasmodium transmission and/or manipulating Anopheles reproduction, which in turn could be used to reduce the malaria burden in Africa. |
format | Online Article Text |
id | pubmed-6708434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67084342019-08-28 Natural Wolbachia infections are common in the major malaria vectors in Central Africa Ayala, Diego Akone‐Ella, Ousman Rahola, Nil Kengne, Pierre Ngangue, Marc F. Mezeme, Fabrice Makanga, Boris K. Nigg, Martha Costantini, Carlo Simard, Frédéric Prugnolle, Franck Roche, Benjamin Duron, Olivier Paupy, Christophe Evol Appl Original Articles During the last decade, the endosymbiont bacterium Wolbachia has emerged as a biological tool for vector disease control. However, for long time, it was believed that Wolbachia was absent in natural populations of Anopheles. The recent discovery that species within the Anopheles gambiae complex host Wolbachia in natural conditions has opened new opportunities for malaria control research in Africa. Here, we investigated the prevalence and diversity of Wolbachia infection in 25 African Anopheles species in Gabon (Central Africa). Our results revealed the presence of Wolbachia in 16 of these species, including the major malaria vectors in this area. The infection prevalence varied greatly among species, confirming that sample size is a key factor to detect the infection. Moreover, our sequencing and phylogenetic analyses showed the important diversity of Wolbachia strains that infect Anopheles. Co‐evolutionary analysis unveiled patterns of Wolbachia transmission within some Anopheles species, suggesting that past independent acquisition events were followed by co‐cladogenesis. The large diversity of Wolbachia strains that infect natural populations of Anopheles offers a promising opportunity to select suitable phenotypes for suppressing Plasmodium transmission and/or manipulating Anopheles reproduction, which in turn could be used to reduce the malaria burden in Africa. John Wiley and Sons Inc. 2019-06-11 /pmc/articles/PMC6708434/ /pubmed/31462916 http://dx.doi.org/10.1111/eva.12804 Text en © 2019 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Ayala, Diego Akone‐Ella, Ousman Rahola, Nil Kengne, Pierre Ngangue, Marc F. Mezeme, Fabrice Makanga, Boris K. Nigg, Martha Costantini, Carlo Simard, Frédéric Prugnolle, Franck Roche, Benjamin Duron, Olivier Paupy, Christophe Natural Wolbachia infections are common in the major malaria vectors in Central Africa |
title | Natural Wolbachia infections are common in the major malaria vectors in Central Africa |
title_full | Natural Wolbachia infections are common in the major malaria vectors in Central Africa |
title_fullStr | Natural Wolbachia infections are common in the major malaria vectors in Central Africa |
title_full_unstemmed | Natural Wolbachia infections are common in the major malaria vectors in Central Africa |
title_short | Natural Wolbachia infections are common in the major malaria vectors in Central Africa |
title_sort | natural wolbachia infections are common in the major malaria vectors in central africa |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708434/ https://www.ncbi.nlm.nih.gov/pubmed/31462916 http://dx.doi.org/10.1111/eva.12804 |
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