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Natural Wolbachia infections are common in the major malaria vectors in Central Africa

During the last decade, the endosymbiont bacterium Wolbachia has emerged as a biological tool for vector disease control. However, for long time, it was believed that Wolbachia was absent in natural populations of Anopheles. The recent discovery that species within the Anopheles gambiae complex host...

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Autores principales: Ayala, Diego, Akone‐Ella, Ousman, Rahola, Nil, Kengne, Pierre, Ngangue, Marc F., Mezeme, Fabrice, Makanga, Boris K., Nigg, Martha, Costantini, Carlo, Simard, Frédéric, Prugnolle, Franck, Roche, Benjamin, Duron, Olivier, Paupy, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708434/
https://www.ncbi.nlm.nih.gov/pubmed/31462916
http://dx.doi.org/10.1111/eva.12804
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author Ayala, Diego
Akone‐Ella, Ousman
Rahola, Nil
Kengne, Pierre
Ngangue, Marc F.
Mezeme, Fabrice
Makanga, Boris K.
Nigg, Martha
Costantini, Carlo
Simard, Frédéric
Prugnolle, Franck
Roche, Benjamin
Duron, Olivier
Paupy, Christophe
author_facet Ayala, Diego
Akone‐Ella, Ousman
Rahola, Nil
Kengne, Pierre
Ngangue, Marc F.
Mezeme, Fabrice
Makanga, Boris K.
Nigg, Martha
Costantini, Carlo
Simard, Frédéric
Prugnolle, Franck
Roche, Benjamin
Duron, Olivier
Paupy, Christophe
author_sort Ayala, Diego
collection PubMed
description During the last decade, the endosymbiont bacterium Wolbachia has emerged as a biological tool for vector disease control. However, for long time, it was believed that Wolbachia was absent in natural populations of Anopheles. The recent discovery that species within the Anopheles gambiae complex host Wolbachia in natural conditions has opened new opportunities for malaria control research in Africa. Here, we investigated the prevalence and diversity of Wolbachia infection in 25 African Anopheles species in Gabon (Central Africa). Our results revealed the presence of Wolbachia in 16 of these species, including the major malaria vectors in this area. The infection prevalence varied greatly among species, confirming that sample size is a key factor to detect the infection. Moreover, our sequencing and phylogenetic analyses showed the important diversity of Wolbachia strains that infect Anopheles. Co‐evolutionary analysis unveiled patterns of Wolbachia transmission within some Anopheles species, suggesting that past independent acquisition events were followed by co‐cladogenesis. The large diversity of Wolbachia strains that infect natural populations of Anopheles offers a promising opportunity to select suitable phenotypes for suppressing Plasmodium transmission and/or manipulating Anopheles reproduction, which in turn could be used to reduce the malaria burden in Africa.
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spelling pubmed-67084342019-08-28 Natural Wolbachia infections are common in the major malaria vectors in Central Africa Ayala, Diego Akone‐Ella, Ousman Rahola, Nil Kengne, Pierre Ngangue, Marc F. Mezeme, Fabrice Makanga, Boris K. Nigg, Martha Costantini, Carlo Simard, Frédéric Prugnolle, Franck Roche, Benjamin Duron, Olivier Paupy, Christophe Evol Appl Original Articles During the last decade, the endosymbiont bacterium Wolbachia has emerged as a biological tool for vector disease control. However, for long time, it was believed that Wolbachia was absent in natural populations of Anopheles. The recent discovery that species within the Anopheles gambiae complex host Wolbachia in natural conditions has opened new opportunities for malaria control research in Africa. Here, we investigated the prevalence and diversity of Wolbachia infection in 25 African Anopheles species in Gabon (Central Africa). Our results revealed the presence of Wolbachia in 16 of these species, including the major malaria vectors in this area. The infection prevalence varied greatly among species, confirming that sample size is a key factor to detect the infection. Moreover, our sequencing and phylogenetic analyses showed the important diversity of Wolbachia strains that infect Anopheles. Co‐evolutionary analysis unveiled patterns of Wolbachia transmission within some Anopheles species, suggesting that past independent acquisition events were followed by co‐cladogenesis. The large diversity of Wolbachia strains that infect natural populations of Anopheles offers a promising opportunity to select suitable phenotypes for suppressing Plasmodium transmission and/or manipulating Anopheles reproduction, which in turn could be used to reduce the malaria burden in Africa. John Wiley and Sons Inc. 2019-06-11 /pmc/articles/PMC6708434/ /pubmed/31462916 http://dx.doi.org/10.1111/eva.12804 Text en © 2019 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Ayala, Diego
Akone‐Ella, Ousman
Rahola, Nil
Kengne, Pierre
Ngangue, Marc F.
Mezeme, Fabrice
Makanga, Boris K.
Nigg, Martha
Costantini, Carlo
Simard, Frédéric
Prugnolle, Franck
Roche, Benjamin
Duron, Olivier
Paupy, Christophe
Natural Wolbachia infections are common in the major malaria vectors in Central Africa
title Natural Wolbachia infections are common in the major malaria vectors in Central Africa
title_full Natural Wolbachia infections are common in the major malaria vectors in Central Africa
title_fullStr Natural Wolbachia infections are common in the major malaria vectors in Central Africa
title_full_unstemmed Natural Wolbachia infections are common in the major malaria vectors in Central Africa
title_short Natural Wolbachia infections are common in the major malaria vectors in Central Africa
title_sort natural wolbachia infections are common in the major malaria vectors in central africa
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708434/
https://www.ncbi.nlm.nih.gov/pubmed/31462916
http://dx.doi.org/10.1111/eva.12804
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