Structural Basis for Gating Pore Current in Periodic Paralysis

Potassium-sensitive Hypokalemic and Normokalemic Periodic Paralysis (HypoPP, NormoPP) are inherited skeletal muscle diseases characterized by episodes of flaccid muscle weakness(1,2). They are caused by mutations in one gating charge in an S4 transmembrane segment in the voltage sensor (VS) of volta...

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Detalles Bibliográficos
Autores principales: Jiang, Daohua, Gamal El-Din, Tamer M., Ing, Christopher, Lu, Peilong, Pomès, Régis, Zheng, Ning, Catterall, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708612/
https://www.ncbi.nlm.nih.gov/pubmed/29769724
http://dx.doi.org/10.1038/s41586-018-0120-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708612/
https://www.ncbi.nlm.nih.gov/pubmed/29769724
http://dx.doi.org/10.1038/s41586-018-0120-4

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