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Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients

The HIV subtype B is the most frequent in Brazil. The HIV subtype B’ codes the amino acids glicine-tryptophan-glicine (GWG) instead of glicine-proline-glicine on the tip of gp120 V3 loop. This variant was associated to a slower HIV progression in mono-infected patients; however, there is no informat...

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Autores principales: Hebeler-Barbosa, Flavia, Massolini, Viviam Milanez, Watanabe, Thais, Silva, Giovanni Faria, Barbosa, Alexandre Naime, Simões, Rafael Plana, Ferrasi, Adriana Camargo, de Andrade Zanotto, Paolo Marinho, de Moura Campos Pardini, Maria Inês, Grotto, Rejane Maria Tommasini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708615/
https://www.ncbi.nlm.nih.gov/pubmed/31335686
http://dx.doi.org/10.1097/MD.0000000000016376
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author Hebeler-Barbosa, Flavia
Massolini, Viviam Milanez
Watanabe, Thais
Silva, Giovanni Faria
Barbosa, Alexandre Naime
Simões, Rafael Plana
Ferrasi, Adriana Camargo
de Andrade Zanotto, Paolo Marinho
de Moura Campos Pardini, Maria Inês
Grotto, Rejane Maria Tommasini
author_facet Hebeler-Barbosa, Flavia
Massolini, Viviam Milanez
Watanabe, Thais
Silva, Giovanni Faria
Barbosa, Alexandre Naime
Simões, Rafael Plana
Ferrasi, Adriana Camargo
de Andrade Zanotto, Paolo Marinho
de Moura Campos Pardini, Maria Inês
Grotto, Rejane Maria Tommasini
author_sort Hebeler-Barbosa, Flavia
collection PubMed
description The HIV subtype B is the most frequent in Brazil. The HIV subtype B’ codes the amino acids glicine-tryptophan-glicine (GWG) instead of glicine-proline-glicine on the tip of gp120 V3 loop. This variant was associated to a slower HIV progression in mono-infected patients; however, there is no information in coinfected patients. This study evaluated the infection progression of HIV variant B’ on the hepatitis C virus presence. RNA isolated from plasma of the 601 infected patients were used to human immunodeficiency virus (HIV) subtyping and to classify the virus according their syncytium-inducing ability. The HIV infection progression was evaluated by clinical and laboratorial data. The results showed a significant association between HIV B’ variant and CD4 count and time of AIDS in HIV mono-infected patients. Notwithstanding the fact that we did not find a direct association between GWG variant and AIDS and in HIV coinfected patients no mitigating effect due to GWG presence was found. We did observe that the association between GWG variant and CD4 counts is lost in coinfected patients. This is first work showing influence of the HIV GWG variant in coinfected patients. Nevertheless, the presence of the GWG variant can indicate a better prognostic in the mono-infected patients.
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spelling pubmed-67086152019-10-01 Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients Hebeler-Barbosa, Flavia Massolini, Viviam Milanez Watanabe, Thais Silva, Giovanni Faria Barbosa, Alexandre Naime Simões, Rafael Plana Ferrasi, Adriana Camargo de Andrade Zanotto, Paolo Marinho de Moura Campos Pardini, Maria Inês Grotto, Rejane Maria Tommasini Medicine (Baltimore) Research Article The HIV subtype B is the most frequent in Brazil. The HIV subtype B’ codes the amino acids glicine-tryptophan-glicine (GWG) instead of glicine-proline-glicine on the tip of gp120 V3 loop. This variant was associated to a slower HIV progression in mono-infected patients; however, there is no information in coinfected patients. This study evaluated the infection progression of HIV variant B’ on the hepatitis C virus presence. RNA isolated from plasma of the 601 infected patients were used to human immunodeficiency virus (HIV) subtyping and to classify the virus according their syncytium-inducing ability. The HIV infection progression was evaluated by clinical and laboratorial data. The results showed a significant association between HIV B’ variant and CD4 count and time of AIDS in HIV mono-infected patients. Notwithstanding the fact that we did not find a direct association between GWG variant and AIDS and in HIV coinfected patients no mitigating effect due to GWG presence was found. We did observe that the association between GWG variant and CD4 counts is lost in coinfected patients. This is first work showing influence of the HIV GWG variant in coinfected patients. Nevertheless, the presence of the GWG variant can indicate a better prognostic in the mono-infected patients. Wolters Kluwer Health 2019-07-19 /pmc/articles/PMC6708615/ /pubmed/31335686 http://dx.doi.org/10.1097/MD.0000000000016376 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Hebeler-Barbosa, Flavia
Massolini, Viviam Milanez
Watanabe, Thais
Silva, Giovanni Faria
Barbosa, Alexandre Naime
Simões, Rafael Plana
Ferrasi, Adriana Camargo
de Andrade Zanotto, Paolo Marinho
de Moura Campos Pardini, Maria Inês
Grotto, Rejane Maria Tommasini
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients
title Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients
title_full Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients
title_fullStr Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients
title_full_unstemmed Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients
title_short Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients
title_sort influence of the hiv gwg variant in the hiv infection progression in mono and hcv coinfected patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708615/
https://www.ncbi.nlm.nih.gov/pubmed/31335686
http://dx.doi.org/10.1097/MD.0000000000016376
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