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Analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease

The human leukocyte antigen (HLA) genes may play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH). The aim of this study was to assess the association of HLA class I and II alleles with NASH and its histological fe...

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Autores principales: Karrar, Azza, Hariharan, Siddharth, Fazel, Yousef, Moosvi, Ali, Houry, Mohamad, Younoszai, Zahra, Jeffers, Thomas, Zheng, Li, Munkhzul, Otgonsuren, Hunt, Sharon, Monge, Fanny, Goodman, Zachary, Younossi, Zobair M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708789/
https://www.ncbi.nlm.nih.gov/pubmed/31393374
http://dx.doi.org/10.1097/MD.0000000000016704
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author Karrar, Azza
Hariharan, Siddharth
Fazel, Yousef
Moosvi, Ali
Houry, Mohamad
Younoszai, Zahra
Jeffers, Thomas
Zheng, Li
Munkhzul, Otgonsuren
Hunt, Sharon
Monge, Fanny
Goodman, Zachary
Younossi, Zobair M.
author_facet Karrar, Azza
Hariharan, Siddharth
Fazel, Yousef
Moosvi, Ali
Houry, Mohamad
Younoszai, Zahra
Jeffers, Thomas
Zheng, Li
Munkhzul, Otgonsuren
Hunt, Sharon
Monge, Fanny
Goodman, Zachary
Younossi, Zobair M.
author_sort Karrar, Azza
collection PubMed
description The human leukocyte antigen (HLA) genes may play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH). The aim of this study was to assess the association of HLA class I and II alleles with NASH and its histological features. Deoxyribonucleic acid (DNA) was extracted from 140 subjects (85 biopsy-proven NAFLD and 55 controls) and genotyped for HLA (-A, -B, -C, -DR1, -DR3, -DQ, and -DP). Liver biopsies were assessed for presence of NASH, degree of fibrosis and inflammation. Multivariate analysis was performed to assess associations between HLA genes and different histologic features of NAFLD. Our data for HLA class I showed that HLA-C∗4 was associated with lower risk for histologic NASH and HLA-C∗6 was protective against portal fibrosis. Conversely, HLA-B∗27 was associated with high-grade hepatic steatosis, while HLA-A∗31 was associated with increased risk for advanced fibrosis. Among HLA class II alleles, HLA-DQA1∗01 was associated with lower risk for NASH while HLA-DRB1∗03 was associated with increased risk for NASH. Our findings indicate that HLA class I and II gene polymorphism may be associated with susceptibility to NASH, fibrosis and other pathologic features and may be involved in the pathogenesis of NAFLD.
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spelling pubmed-67087892019-10-01 Analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease Karrar, Azza Hariharan, Siddharth Fazel, Yousef Moosvi, Ali Houry, Mohamad Younoszai, Zahra Jeffers, Thomas Zheng, Li Munkhzul, Otgonsuren Hunt, Sharon Monge, Fanny Goodman, Zachary Younossi, Zobair M. Medicine (Baltimore) Research Article The human leukocyte antigen (HLA) genes may play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH). The aim of this study was to assess the association of HLA class I and II alleles with NASH and its histological features. Deoxyribonucleic acid (DNA) was extracted from 140 subjects (85 biopsy-proven NAFLD and 55 controls) and genotyped for HLA (-A, -B, -C, -DR1, -DR3, -DQ, and -DP). Liver biopsies were assessed for presence of NASH, degree of fibrosis and inflammation. Multivariate analysis was performed to assess associations between HLA genes and different histologic features of NAFLD. Our data for HLA class I showed that HLA-C∗4 was associated with lower risk for histologic NASH and HLA-C∗6 was protective against portal fibrosis. Conversely, HLA-B∗27 was associated with high-grade hepatic steatosis, while HLA-A∗31 was associated with increased risk for advanced fibrosis. Among HLA class II alleles, HLA-DQA1∗01 was associated with lower risk for NASH while HLA-DRB1∗03 was associated with increased risk for NASH. Our findings indicate that HLA class I and II gene polymorphism may be associated with susceptibility to NASH, fibrosis and other pathologic features and may be involved in the pathogenesis of NAFLD. Wolters Kluwer Health 2019-08-09 /pmc/articles/PMC6708789/ /pubmed/31393374 http://dx.doi.org/10.1097/MD.0000000000016704 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Karrar, Azza
Hariharan, Siddharth
Fazel, Yousef
Moosvi, Ali
Houry, Mohamad
Younoszai, Zahra
Jeffers, Thomas
Zheng, Li
Munkhzul, Otgonsuren
Hunt, Sharon
Monge, Fanny
Goodman, Zachary
Younossi, Zobair M.
Analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease
title Analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease
title_full Analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease
title_fullStr Analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease
title_full_unstemmed Analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease
title_short Analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease
title_sort analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708789/
https://www.ncbi.nlm.nih.gov/pubmed/31393374
http://dx.doi.org/10.1097/MD.0000000000016704
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