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Association between cannabis use and complications related to ulcerative colitis in hospitalized patients: A propensity matched retrospective cohort study

Ulcerative colitis (UC) is a chronic inflammatory process that is occasionally associated with complications that cause significant morbidity and mortality. Studies in experimental animal models have demonstrated a beneficial effect of cannabis on intestinal inflammation. It is however unknown if th...

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Autores principales: Mbachi, Chimezie, Attar, Bashar, Oyenubi, Olamide, Yuchen, Wang, Efesomwan, Aisien, Paintsil, Isaac, Madhu, Mathew, Ajiboye, Oyintayo, Roberto, Simons-Linares C., Trick, William E., Kotwal, Vikram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708902/
https://www.ncbi.nlm.nih.gov/pubmed/31393356
http://dx.doi.org/10.1097/MD.0000000000016551
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author Mbachi, Chimezie
Attar, Bashar
Oyenubi, Olamide
Yuchen, Wang
Efesomwan, Aisien
Paintsil, Isaac
Madhu, Mathew
Ajiboye, Oyintayo
Roberto, Simons-Linares C.
Trick, William E.
Kotwal, Vikram
author_facet Mbachi, Chimezie
Attar, Bashar
Oyenubi, Olamide
Yuchen, Wang
Efesomwan, Aisien
Paintsil, Isaac
Madhu, Mathew
Ajiboye, Oyintayo
Roberto, Simons-Linares C.
Trick, William E.
Kotwal, Vikram
author_sort Mbachi, Chimezie
collection PubMed
description Ulcerative colitis (UC) is a chronic inflammatory process that is occasionally associated with complications that cause significant morbidity and mortality. Studies in experimental animal models have demonstrated a beneficial effect of cannabis on intestinal inflammation. It is however unknown if this corresponds to fewer complications for patients with Ulcerative Colitis. We aimed to compare the prevalence of UC related complications and certain key clinical endpoints among cannabis users and nonusers hospitalized with a primary diagnosis of UC, or primary diagnosis of a UC-related complication with a secondary diagnosis of UC. Using data from the Healthcare Cost and Utilization Project-National Inpatient Sample (NIS) during 2010–2014, a total of 298 cannabis users with UC were compared to a propensity score matched group of nonusers with UC. We evaluated several UC-related complications and clinical endpoints. Within our matched cohort, prevalence of partial or total colectomy was lower in cannabis users compared to nonusers (4.4% vs 9.7%, P = .010) and there was a trend toward a lower prevalence of bowel obstruction (6.4% vs 10.7%, P = .057). Cannabis users had shorter hospital length-of-stay (4.5 vs 5.7 days P < .007) compared to their nonuser counterparts. Cannabis use may mitigate some of the well described complications of UC among hospitalized patients. Our findings need further evaluation, ideally through more rigorous clinical trials.
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spelling pubmed-67089022019-10-01 Association between cannabis use and complications related to ulcerative colitis in hospitalized patients: A propensity matched retrospective cohort study Mbachi, Chimezie Attar, Bashar Oyenubi, Olamide Yuchen, Wang Efesomwan, Aisien Paintsil, Isaac Madhu, Mathew Ajiboye, Oyintayo Roberto, Simons-Linares C. Trick, William E. Kotwal, Vikram Medicine (Baltimore) Research Article Ulcerative colitis (UC) is a chronic inflammatory process that is occasionally associated with complications that cause significant morbidity and mortality. Studies in experimental animal models have demonstrated a beneficial effect of cannabis on intestinal inflammation. It is however unknown if this corresponds to fewer complications for patients with Ulcerative Colitis. We aimed to compare the prevalence of UC related complications and certain key clinical endpoints among cannabis users and nonusers hospitalized with a primary diagnosis of UC, or primary diagnosis of a UC-related complication with a secondary diagnosis of UC. Using data from the Healthcare Cost and Utilization Project-National Inpatient Sample (NIS) during 2010–2014, a total of 298 cannabis users with UC were compared to a propensity score matched group of nonusers with UC. We evaluated several UC-related complications and clinical endpoints. Within our matched cohort, prevalence of partial or total colectomy was lower in cannabis users compared to nonusers (4.4% vs 9.7%, P = .010) and there was a trend toward a lower prevalence of bowel obstruction (6.4% vs 10.7%, P = .057). Cannabis users had shorter hospital length-of-stay (4.5 vs 5.7 days P < .007) compared to their nonuser counterparts. Cannabis use may mitigate some of the well described complications of UC among hospitalized patients. Our findings need further evaluation, ideally through more rigorous clinical trials. Wolters Kluwer Health 2019-08-09 /pmc/articles/PMC6708902/ /pubmed/31393356 http://dx.doi.org/10.1097/MD.0000000000016551 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Mbachi, Chimezie
Attar, Bashar
Oyenubi, Olamide
Yuchen, Wang
Efesomwan, Aisien
Paintsil, Isaac
Madhu, Mathew
Ajiboye, Oyintayo
Roberto, Simons-Linares C.
Trick, William E.
Kotwal, Vikram
Association between cannabis use and complications related to ulcerative colitis in hospitalized patients: A propensity matched retrospective cohort study
title Association between cannabis use and complications related to ulcerative colitis in hospitalized patients: A propensity matched retrospective cohort study
title_full Association between cannabis use and complications related to ulcerative colitis in hospitalized patients: A propensity matched retrospective cohort study
title_fullStr Association between cannabis use and complications related to ulcerative colitis in hospitalized patients: A propensity matched retrospective cohort study
title_full_unstemmed Association between cannabis use and complications related to ulcerative colitis in hospitalized patients: A propensity matched retrospective cohort study
title_short Association between cannabis use and complications related to ulcerative colitis in hospitalized patients: A propensity matched retrospective cohort study
title_sort association between cannabis use and complications related to ulcerative colitis in hospitalized patients: a propensity matched retrospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708902/
https://www.ncbi.nlm.nih.gov/pubmed/31393356
http://dx.doi.org/10.1097/MD.0000000000016551
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