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Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series
Amniotic membrane (AM) and umbilical cord (UC) are well known to have anti-inflammatory properties and have been shown to promote healing in various orthopedic indications. This study investigated whether intra-articular injection of AM/UC particulate matrix promotes healing of partial rotator cuff...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709267/ https://www.ncbi.nlm.nih.gov/pubmed/31348285 http://dx.doi.org/10.1097/MD.0000000000016569 |
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author | Ackley, J. Freeland Kolosky, Michael Gurin, Danielle Hampton, Robert Masin, Richard Krahe, David |
author_facet | Ackley, J. Freeland Kolosky, Michael Gurin, Danielle Hampton, Robert Masin, Richard Krahe, David |
author_sort | Ackley, J. Freeland |
collection | PubMed |
description | Amniotic membrane (AM) and umbilical cord (UC) are well known to have anti-inflammatory properties and have been shown to promote healing in various orthopedic indications. This study investigated whether intra-articular injection of AM/UC particulate matrix promotes healing of partial rotator cuff tears (RCTs). A case series was performed on 10 patients that received injection of 50 mg AM/UC for partial RCTs that were refractory to conservative treatment. Outcomes included Penn Shoulder Score (PSS) questionnaire, range of motion examination, and magnetic resonance imaging (MRI) analysis before and at 6 months. Final MRI analysis was performed by a musculoskeletal radiologist in a blinded fashion. Average PSS score (out of 100) increased from 46.8 ± 23.7 at baseline to 82.0 ± 19.1 at 6 months. The average PSS sub-scores of pain, satisfaction, and function increased 78.4%, 37.1%, and 82.3% from baseline, respectively. The subject's range of motion was 77.9% at baseline and increased to 99.9% at 6-months. Follow-up MRI scans did not demonstrate any significant change in RCT size. No adverse events were noted. This small case series provides preliminary data for use of cryopreserved AM/UC particulate matrix in patients with refractory partial RCTs. |
format | Online Article Text |
id | pubmed-6709267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-67092672019-10-01 Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series Ackley, J. Freeland Kolosky, Michael Gurin, Danielle Hampton, Robert Masin, Richard Krahe, David Medicine (Baltimore) Research Article Amniotic membrane (AM) and umbilical cord (UC) are well known to have anti-inflammatory properties and have been shown to promote healing in various orthopedic indications. This study investigated whether intra-articular injection of AM/UC particulate matrix promotes healing of partial rotator cuff tears (RCTs). A case series was performed on 10 patients that received injection of 50 mg AM/UC for partial RCTs that were refractory to conservative treatment. Outcomes included Penn Shoulder Score (PSS) questionnaire, range of motion examination, and magnetic resonance imaging (MRI) analysis before and at 6 months. Final MRI analysis was performed by a musculoskeletal radiologist in a blinded fashion. Average PSS score (out of 100) increased from 46.8 ± 23.7 at baseline to 82.0 ± 19.1 at 6 months. The average PSS sub-scores of pain, satisfaction, and function increased 78.4%, 37.1%, and 82.3% from baseline, respectively. The subject's range of motion was 77.9% at baseline and increased to 99.9% at 6-months. Follow-up MRI scans did not demonstrate any significant change in RCT size. No adverse events were noted. This small case series provides preliminary data for use of cryopreserved AM/UC particulate matrix in patients with refractory partial RCTs. Wolters Kluwer Health 2019-07-26 /pmc/articles/PMC6709267/ /pubmed/31348285 http://dx.doi.org/10.1097/MD.0000000000016569 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Research Article Ackley, J. Freeland Kolosky, Michael Gurin, Danielle Hampton, Robert Masin, Richard Krahe, David Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series |
title | Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series |
title_full | Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series |
title_fullStr | Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series |
title_full_unstemmed | Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series |
title_short | Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series |
title_sort | cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: a case series |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709267/ https://www.ncbi.nlm.nih.gov/pubmed/31348285 http://dx.doi.org/10.1097/MD.0000000000016569 |
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