Cargando…

Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series

Amniotic membrane (AM) and umbilical cord (UC) are well known to have anti-inflammatory properties and have been shown to promote healing in various orthopedic indications. This study investigated whether intra-articular injection of AM/UC particulate matrix promotes healing of partial rotator cuff...

Descripción completa

Detalles Bibliográficos
Autores principales: Ackley, J. Freeland, Kolosky, Michael, Gurin, Danielle, Hampton, Robert, Masin, Richard, Krahe, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709267/
https://www.ncbi.nlm.nih.gov/pubmed/31348285
http://dx.doi.org/10.1097/MD.0000000000016569
_version_ 1783446170778992640
author Ackley, J. Freeland
Kolosky, Michael
Gurin, Danielle
Hampton, Robert
Masin, Richard
Krahe, David
author_facet Ackley, J. Freeland
Kolosky, Michael
Gurin, Danielle
Hampton, Robert
Masin, Richard
Krahe, David
author_sort Ackley, J. Freeland
collection PubMed
description Amniotic membrane (AM) and umbilical cord (UC) are well known to have anti-inflammatory properties and have been shown to promote healing in various orthopedic indications. This study investigated whether intra-articular injection of AM/UC particulate matrix promotes healing of partial rotator cuff tears (RCTs). A case series was performed on 10 patients that received injection of 50 mg AM/UC for partial RCTs that were refractory to conservative treatment. Outcomes included Penn Shoulder Score (PSS) questionnaire, range of motion examination, and magnetic resonance imaging (MRI) analysis before and at 6 months. Final MRI analysis was performed by a musculoskeletal radiologist in a blinded fashion. Average PSS score (out of 100) increased from 46.8 ± 23.7 at baseline to 82.0 ± 19.1 at 6 months. The average PSS sub-scores of pain, satisfaction, and function increased 78.4%, 37.1%, and 82.3% from baseline, respectively. The subject's range of motion was 77.9% at baseline and increased to 99.9% at 6-months. Follow-up MRI scans did not demonstrate any significant change in RCT size. No adverse events were noted. This small case series provides preliminary data for use of cryopreserved AM/UC particulate matrix in patients with refractory partial RCTs.
format Online
Article
Text
id pubmed-6709267
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-67092672019-10-01 Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series Ackley, J. Freeland Kolosky, Michael Gurin, Danielle Hampton, Robert Masin, Richard Krahe, David Medicine (Baltimore) Research Article Amniotic membrane (AM) and umbilical cord (UC) are well known to have anti-inflammatory properties and have been shown to promote healing in various orthopedic indications. This study investigated whether intra-articular injection of AM/UC particulate matrix promotes healing of partial rotator cuff tears (RCTs). A case series was performed on 10 patients that received injection of 50 mg AM/UC for partial RCTs that were refractory to conservative treatment. Outcomes included Penn Shoulder Score (PSS) questionnaire, range of motion examination, and magnetic resonance imaging (MRI) analysis before and at 6 months. Final MRI analysis was performed by a musculoskeletal radiologist in a blinded fashion. Average PSS score (out of 100) increased from 46.8 ± 23.7 at baseline to 82.0 ± 19.1 at 6 months. The average PSS sub-scores of pain, satisfaction, and function increased 78.4%, 37.1%, and 82.3% from baseline, respectively. The subject's range of motion was 77.9% at baseline and increased to 99.9% at 6-months. Follow-up MRI scans did not demonstrate any significant change in RCT size. No adverse events were noted. This small case series provides preliminary data for use of cryopreserved AM/UC particulate matrix in patients with refractory partial RCTs. Wolters Kluwer Health 2019-07-26 /pmc/articles/PMC6709267/ /pubmed/31348285 http://dx.doi.org/10.1097/MD.0000000000016569 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Ackley, J. Freeland
Kolosky, Michael
Gurin, Danielle
Hampton, Robert
Masin, Richard
Krahe, David
Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series
title Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series
title_full Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series
title_fullStr Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series
title_full_unstemmed Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series
title_short Cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: A case series
title_sort cryopreserved amniotic membrane and umbilical cord particulate matrix for partial rotator cuff tears: a case series
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709267/
https://www.ncbi.nlm.nih.gov/pubmed/31348285
http://dx.doi.org/10.1097/MD.0000000000016569
work_keys_str_mv AT ackleyjfreeland cryopreservedamnioticmembraneandumbilicalcordparticulatematrixforpartialrotatorcufftearsacaseseries
AT koloskymichael cryopreservedamnioticmembraneandumbilicalcordparticulatematrixforpartialrotatorcufftearsacaseseries
AT gurindanielle cryopreservedamnioticmembraneandumbilicalcordparticulatematrixforpartialrotatorcufftearsacaseseries
AT hamptonrobert cryopreservedamnioticmembraneandumbilicalcordparticulatematrixforpartialrotatorcufftearsacaseseries
AT masinrichard cryopreservedamnioticmembraneandumbilicalcordparticulatematrixforpartialrotatorcufftearsacaseseries
AT krahedavid cryopreservedamnioticmembraneandumbilicalcordparticulatematrixforpartialrotatorcufftearsacaseseries