Cargando…
Bucillamine-induced Pneumonitis in a Patient with Rheumatoid Arthritis-associated Interstitial Pneumonia: A Case Report and Review of the Literature
An 81-year-old woman with rheumatoid arthritis (RA) who had been treated with bucillamine presented with dyspnea. Computed tomography of the chest showed ground-glass opacities and consolidations in both lungs and honeycombing in both basal lung areas. An elevation of the serum Krebs von den Lungen-...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709319/ https://www.ncbi.nlm.nih.gov/pubmed/30918198 http://dx.doi.org/10.2169/internalmedicine.2515-18 |
_version_ | 1783446182934085632 |
---|---|
author | Fukada, Atsuki Toyoshima, Mikio Nozue, Tsuyoshi Suda, Takafumi |
author_facet | Fukada, Atsuki Toyoshima, Mikio Nozue, Tsuyoshi Suda, Takafumi |
author_sort | Fukada, Atsuki |
collection | PubMed |
description | An 81-year-old woman with rheumatoid arthritis (RA) who had been treated with bucillamine presented with dyspnea. Computed tomography of the chest showed ground-glass opacities and consolidations in both lungs and honeycombing in both basal lung areas. An elevation of the serum Krebs von den Lungen-6 level and hypoxemia were seen. Lymphocytosis with a decreased CD4/CD8 ratio was seen in the bronchoalveolar lavage fluid. A transbronchial lung biopsy specimen showed organizing pneumonia. Based on a diagnosis of bucillamine-induced pneumonitis (BIP) with RA-associated pre-existing interstitial pneumonia, she was successfully treated with the cessation of bucillamine and systemic corticosteroid therapy. The risk factors and prognosis of BIP are discussed. |
format | Online Article Text |
id | pubmed-6709319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-67093192019-08-26 Bucillamine-induced Pneumonitis in a Patient with Rheumatoid Arthritis-associated Interstitial Pneumonia: A Case Report and Review of the Literature Fukada, Atsuki Toyoshima, Mikio Nozue, Tsuyoshi Suda, Takafumi Intern Med Case Report An 81-year-old woman with rheumatoid arthritis (RA) who had been treated with bucillamine presented with dyspnea. Computed tomography of the chest showed ground-glass opacities and consolidations in both lungs and honeycombing in both basal lung areas. An elevation of the serum Krebs von den Lungen-6 level and hypoxemia were seen. Lymphocytosis with a decreased CD4/CD8 ratio was seen in the bronchoalveolar lavage fluid. A transbronchial lung biopsy specimen showed organizing pneumonia. Based on a diagnosis of bucillamine-induced pneumonitis (BIP) with RA-associated pre-existing interstitial pneumonia, she was successfully treated with the cessation of bucillamine and systemic corticosteroid therapy. The risk factors and prognosis of BIP are discussed. The Japanese Society of Internal Medicine 2019-03-28 2019-08-01 /pmc/articles/PMC6709319/ /pubmed/30918198 http://dx.doi.org/10.2169/internalmedicine.2515-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Fukada, Atsuki Toyoshima, Mikio Nozue, Tsuyoshi Suda, Takafumi Bucillamine-induced Pneumonitis in a Patient with Rheumatoid Arthritis-associated Interstitial Pneumonia: A Case Report and Review of the Literature |
title | Bucillamine-induced Pneumonitis in a Patient with Rheumatoid Arthritis-associated Interstitial Pneumonia: A Case Report and Review of the Literature |
title_full | Bucillamine-induced Pneumonitis in a Patient with Rheumatoid Arthritis-associated Interstitial Pneumonia: A Case Report and Review of the Literature |
title_fullStr | Bucillamine-induced Pneumonitis in a Patient with Rheumatoid Arthritis-associated Interstitial Pneumonia: A Case Report and Review of the Literature |
title_full_unstemmed | Bucillamine-induced Pneumonitis in a Patient with Rheumatoid Arthritis-associated Interstitial Pneumonia: A Case Report and Review of the Literature |
title_short | Bucillamine-induced Pneumonitis in a Patient with Rheumatoid Arthritis-associated Interstitial Pneumonia: A Case Report and Review of the Literature |
title_sort | bucillamine-induced pneumonitis in a patient with rheumatoid arthritis-associated interstitial pneumonia: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709319/ https://www.ncbi.nlm.nih.gov/pubmed/30918198 http://dx.doi.org/10.2169/internalmedicine.2515-18 |
work_keys_str_mv | AT fukadaatsuki bucillamineinducedpneumonitisinapatientwithrheumatoidarthritisassociatedinterstitialpneumoniaacasereportandreviewoftheliterature AT toyoshimamikio bucillamineinducedpneumonitisinapatientwithrheumatoidarthritisassociatedinterstitialpneumoniaacasereportandreviewoftheliterature AT nozuetsuyoshi bucillamineinducedpneumonitisinapatientwithrheumatoidarthritisassociatedinterstitialpneumoniaacasereportandreviewoftheliterature AT sudatakafumi bucillamineinducedpneumonitisinapatientwithrheumatoidarthritisassociatedinterstitialpneumoniaacasereportandreviewoftheliterature |