Synthesis, characterization, and mechanistic studies of a gold nanoparticle–amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity

BACKGROUND: Amphotericin B (AmB) as a liposomal formulation of AmBisome is the first line of treatment for the disease, visceral leishmaniasis, caused by the parasite Leishmania donovani. However, nephrotoxicity is very common due to poor water solubility and aggregation of AmB. This study aimed to...

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Detalles Bibliográficos
Autores principales: Kumar, Prakash, Shivam, Pushkar, Mandal, Saptarshi, Prasanna, Pragya, Kumar, Saurabh, Prasad, Surendra Rajit, Kumar, Ashish, Das, Prolay, Ali, Vahab, Singh, Shubhankar Kumar, Mandal, Debabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709383/
https://www.ncbi.nlm.nih.gov/pubmed/31686803
http://dx.doi.org/10.2147/IJN.S196421

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