Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a major bacterial pathogen associated with a rising prevalence of antibiotic resistance. We evaluated the resistance mechanisms of P. aeruginosa against POL7080, a species-specific, first-in-class antibiotic in clinical trials that targets the lipopolysaccharide transport p...

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Detalles Bibliográficos
Autores principales: Romano, Keith P., Warrier, Thulasi, Poulsen, Bradley E., Nguyen, Phuong H., Loftis, Alexander R., Saebi, Azin, Pentelute, Bradley L., Hung, Deborah T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709506/
https://www.ncbi.nlm.nih.gov/pubmed/31235628
http://dx.doi.org/10.1128/AAC.00511-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709506/
https://www.ncbi.nlm.nih.gov/pubmed/31235628
http://dx.doi.org/10.1128/AAC.00511-19

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