Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D

Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or NRas. Structures of Ras G13D in the three isoforms show an ope...

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Detalles Bibliográficos
Autores principales: Johnson, Christian W., Lin, Yi-Jang, Reid, Derion, Parker, Jillian, Pavlopoulos, Spiro, Dischinger, Patrick, Graveel, Carrie, Aguirre, Andrew J., Steensma, Matthew, Haigis, Kevin M., Mattos, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709685/
https://www.ncbi.nlm.nih.gov/pubmed/31390567
http://dx.doi.org/10.1016/j.celrep.2019.07.026

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