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Age-related changes in human sperm DNA integrity

Abnormal standard semen characteristics and reduced sperm chromatin maturity can appear with increasing male age. However, the influence of paternal age on semen parameters is still controversial. Therefore, this study was designed to estimate the influence of paternal age not only on conventional s...

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Autores principales: Rosiak-Gill, Aleksandra, Gill, Kamil, Jakubik, Joanna, Fraczek, Monika, Patorski, Lukasz, Gaczarzewicz, Dariusz, Kurzawa, Rafał, Kurpisz, Maciej, Piasecka, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710060/
https://www.ncbi.nlm.nih.gov/pubmed/31412318
http://dx.doi.org/10.18632/aging.102120
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author Rosiak-Gill, Aleksandra
Gill, Kamil
Jakubik, Joanna
Fraczek, Monika
Patorski, Lukasz
Gaczarzewicz, Dariusz
Kurzawa, Rafał
Kurpisz, Maciej
Piasecka, Malgorzata
author_facet Rosiak-Gill, Aleksandra
Gill, Kamil
Jakubik, Joanna
Fraczek, Monika
Patorski, Lukasz
Gaczarzewicz, Dariusz
Kurzawa, Rafał
Kurpisz, Maciej
Piasecka, Malgorzata
author_sort Rosiak-Gill, Aleksandra
collection PubMed
description Abnormal standard semen characteristics and reduced sperm chromatin maturity can appear with increasing male age. However, the influence of paternal age on semen parameters is still controversial. Therefore, this study was designed to estimate the influence of paternal age not only on conventional semen characteristics but also on sperm DNA integrity. This research was carried out on ejaculated sperm cells obtained from men (n = 1124) aged ≥40 y and <40 y. Our data revealed a decreased semen volume and an increased percentage of DFI (sperm DNA fragmentation index) in older men compared to younger men in the entire study cohort, in men with normozoospermia and in men with abnormal semen parameters. Moreover, there was a higher incidence of sperm DNA damage (>10% DFI, low fertility potential) in the groups of men aged ≥40 y than in the groups of men aged <40 y. Older men had over twice the odds ratio for high sperm DNA damage as younger men. Our findings suggest a detrimental effect of advanced paternal age on sperm chromatin integrity. The data show that the evaluation of sperm DNA has greater clinical utility than standard semen analysis in case of male fertility potential assessment.
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spelling pubmed-67100602019-09-05 Age-related changes in human sperm DNA integrity Rosiak-Gill, Aleksandra Gill, Kamil Jakubik, Joanna Fraczek, Monika Patorski, Lukasz Gaczarzewicz, Dariusz Kurzawa, Rafał Kurpisz, Maciej Piasecka, Malgorzata Aging (Albany NY) Research Paper Abnormal standard semen characteristics and reduced sperm chromatin maturity can appear with increasing male age. However, the influence of paternal age on semen parameters is still controversial. Therefore, this study was designed to estimate the influence of paternal age not only on conventional semen characteristics but also on sperm DNA integrity. This research was carried out on ejaculated sperm cells obtained from men (n = 1124) aged ≥40 y and <40 y. Our data revealed a decreased semen volume and an increased percentage of DFI (sperm DNA fragmentation index) in older men compared to younger men in the entire study cohort, in men with normozoospermia and in men with abnormal semen parameters. Moreover, there was a higher incidence of sperm DNA damage (>10% DFI, low fertility potential) in the groups of men aged ≥40 y than in the groups of men aged <40 y. Older men had over twice the odds ratio for high sperm DNA damage as younger men. Our findings suggest a detrimental effect of advanced paternal age on sperm chromatin integrity. The data show that the evaluation of sperm DNA has greater clinical utility than standard semen analysis in case of male fertility potential assessment. Impact Journals 2019-08-13 /pmc/articles/PMC6710060/ /pubmed/31412318 http://dx.doi.org/10.18632/aging.102120 Text en Copyright © 2019 Rosiak-Gill et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Rosiak-Gill, Aleksandra
Gill, Kamil
Jakubik, Joanna
Fraczek, Monika
Patorski, Lukasz
Gaczarzewicz, Dariusz
Kurzawa, Rafał
Kurpisz, Maciej
Piasecka, Malgorzata
Age-related changes in human sperm DNA integrity
title Age-related changes in human sperm DNA integrity
title_full Age-related changes in human sperm DNA integrity
title_fullStr Age-related changes in human sperm DNA integrity
title_full_unstemmed Age-related changes in human sperm DNA integrity
title_short Age-related changes in human sperm DNA integrity
title_sort age-related changes in human sperm dna integrity
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710060/
https://www.ncbi.nlm.nih.gov/pubmed/31412318
http://dx.doi.org/10.18632/aging.102120
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