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Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients
OBJECTIVE: To compare the novel model‐based hemodynamic physiomarker of Dynamic Vasomotor Reactivity (DVR) with biomarkers based on Diffusion Tensor Imaging (DTI) and some widely used neurocognitive scores in terms of their ability to delineate patients with amnestic Mild Cognitive Impairment (MCI)...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710205/ https://www.ncbi.nlm.nih.gov/pubmed/31286695 http://dx.doi.org/10.1002/brb3.1356 |
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author | Marmarelis, Vasilis Z. Shin, Dae C. Tarumi, Takashi Zhang, Rong |
author_facet | Marmarelis, Vasilis Z. Shin, Dae C. Tarumi, Takashi Zhang, Rong |
author_sort | Marmarelis, Vasilis Z. |
collection | PubMed |
description | OBJECTIVE: To compare the novel model‐based hemodynamic physiomarker of Dynamic Vasomotor Reactivity (DVR) with biomarkers based on Diffusion Tensor Imaging (DTI) and some widely used neurocognitive scores in terms of their ability to delineate patients with amnestic Mild Cognitive Impairment (MCI) from age‐matched cognitively normal controls. MATERIALS & METHODS: The model‐based DVR and MRI‐based DTI markers were obtained from 36 patients with amnestic MCI and 16 age‐matched controls without cognitive impairment, for whom widely used neurocognitive scores were available. These markers and scores were subsequently compared in terms of statistical delineation between patients and controls. RESULTS: It was found that statistically significant delineation between MCI patients and controls was comparable for DVR or DTI markers (p < 0.01). The performance of both types of markers was consistent with the scores of some (but not all) widely used neurocognitive tests. CONCLUSION: Since DTI offers a measure of cerebral white matter integrity, the results suggest that the model‐based hemodynamic marker of DVR may correlate with cognitive impairment due to white matter lesions. This finding is consistent with the hypothesis that dysregulation of cerebral microcirculation may be an early cause of cognitive impairment, which has been recently corroborated by several studies. |
format | Online Article Text |
id | pubmed-6710205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67102052019-08-28 Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients Marmarelis, Vasilis Z. Shin, Dae C. Tarumi, Takashi Zhang, Rong Brain Behav Original Research OBJECTIVE: To compare the novel model‐based hemodynamic physiomarker of Dynamic Vasomotor Reactivity (DVR) with biomarkers based on Diffusion Tensor Imaging (DTI) and some widely used neurocognitive scores in terms of their ability to delineate patients with amnestic Mild Cognitive Impairment (MCI) from age‐matched cognitively normal controls. MATERIALS & METHODS: The model‐based DVR and MRI‐based DTI markers were obtained from 36 patients with amnestic MCI and 16 age‐matched controls without cognitive impairment, for whom widely used neurocognitive scores were available. These markers and scores were subsequently compared in terms of statistical delineation between patients and controls. RESULTS: It was found that statistically significant delineation between MCI patients and controls was comparable for DVR or DTI markers (p < 0.01). The performance of both types of markers was consistent with the scores of some (but not all) widely used neurocognitive tests. CONCLUSION: Since DTI offers a measure of cerebral white matter integrity, the results suggest that the model‐based hemodynamic marker of DVR may correlate with cognitive impairment due to white matter lesions. This finding is consistent with the hypothesis that dysregulation of cerebral microcirculation may be an early cause of cognitive impairment, which has been recently corroborated by several studies. John Wiley and Sons Inc. 2019-07-09 /pmc/articles/PMC6710205/ /pubmed/31286695 http://dx.doi.org/10.1002/brb3.1356 Text en © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Marmarelis, Vasilis Z. Shin, Dae C. Tarumi, Takashi Zhang, Rong Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title | Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_full | Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_fullStr | Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_full_unstemmed | Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_short | Comparing model‐based cerebrovascular physiomarkers with DTI biomarkers in MCI patients |
title_sort | comparing model‐based cerebrovascular physiomarkers with dti biomarkers in mci patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710205/ https://www.ncbi.nlm.nih.gov/pubmed/31286695 http://dx.doi.org/10.1002/brb3.1356 |
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