Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis()

We recently described a positive feedback loop connecting c-MYC, NAMPT, DBC1 and SIRT1 that contributes to unrestricted cancer cell proliferation. Here we determine the relevance of the loop for serrated route intestinal tumorigenesis using genetically well-defined Braf(V600E) and K-ras(G12D) mouse...

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Detalles Bibliográficos
Autores principales: Brandl, Lydia, Zhang, Yina, Kirstein, Nina, Sendelhofert, Andrea, Boos, Sophie Luise, Jung, Peter, Greten, Florian, Rad, Roland, Menssen, Antje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710297/
https://www.ncbi.nlm.nih.gov/pubmed/31442917
http://dx.doi.org/10.1016/j.neo.2019.07.009

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