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Quantitative Structure Activity Relationship Studies and Molecular Dynamics Simulations of 2-(Aryloxyacetyl)cyclohexane-1,3-Diones Derivatives as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a significant enzyme in the biosynthesis of plastoquinone and tocopherol. Moreover, it is also a potential target to develop new herbicide. The technology of computer-aided drug design (CADD) is a useful tool in the efficient discovery of new HPPD inhibi...

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Detalles Bibliográficos
Autores principales:	Fu, Ying, Liu, Yong-Xuan, Yi, Ke-Han, Li, Ming-Qiang, Li, Jia-Zhong, Ye, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710436/ https://www.ncbi.nlm.nih.gov/pubmed/31482084 http://dx.doi.org/10.3389/fchem.2019.00556

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