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Assessment of Antibody Interference of Enfuvirtide (T20) Function Shows Assay Dependent Variability

BACKGROUND: During HIV infection, fusion of the viral and cellular membranes is dependent on folding of the gp41 trimer into a six-helix bundle. Fusion inhibitors, such as the antiretroviral Enfuvirtide (T20), interfere with the formation of the gp41 six-helix bundle. Recent in vitro studies reveal...

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Detalles Bibliográficos
Autores principales:	Smith, Michele, Hoffman, Jonathon, Sojar, Hakimuddin, Aalinkeel, Ravikumar, Hsiao, Chiu-Bin, Hicar, Mark Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710457/ https://www.ncbi.nlm.nih.gov/pubmed/30836922 http://dx.doi.org/10.2174/1570162X17666190228154850

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