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Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease (MND) caused by a mutant androgen receptor (AR) containing an elongated polyglutamine (polyQ) tract. ARpolyQ toxicity is triggered by androgenic AR ligands, which induce aberrant conformations (misfolding) of the ARpolyQ pro...

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Detalles Bibliográficos
Autores principales:	Cicardi, Maria Elena, Cristofani, Riccardo, Crippa, Valeria, Ferrari, Veronica, Tedesco, Barbara, Casarotto, Elena, Chierichetti, Marta, Galbiati, Mariarita, Piccolella, Margherita, Messi, Elio, Carra, Serena, Pennuto, Maria, Rusmini, Paola, Poletti, Angelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710630/ https://www.ncbi.nlm.nih.gov/pubmed/31481932 http://dx.doi.org/10.3389/fendo.2019.00569

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