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Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal Logistic Type Laws
Drug release is a complex phenomenon due to the large number of interdependent side effects that occur simultaneously, involving strong nonlinear dynamics. Therefore, since their theoretical description is difficult in the classical mathematics modelling, we have built a theoretical model based on l...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710764/ https://www.ncbi.nlm.nih.gov/pubmed/31485257 http://dx.doi.org/10.1155/2019/4091464 |
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author | Craciun, Anda-Mihaela Barhalescu, Mihaela Luminita Agop, Maricel Ochiuz, Lăcrămioara |
author_facet | Craciun, Anda-Mihaela Barhalescu, Mihaela Luminita Agop, Maricel Ochiuz, Lăcrămioara |
author_sort | Craciun, Anda-Mihaela |
collection | PubMed |
description | Drug release is a complex phenomenon due to the large number of interdependent side effects that occur simultaneously, involving strong nonlinear dynamics. Therefore, since their theoretical description is difficult in the classical mathematics modelling, we have built a theoretical model based on logistic type laws, validated by the correlations with the experimental data, in a special case of drug release from hydrogels. The novelty of our approach is the implementation of multifractality in logistic type laws, situation in which any chaotic system, characterized by a small number of nonlinear interactions, gets memory and, implicitly, characterization through a large number of nonlinear interactions. In other words, the complex system polymer-drug matrix becomes “pseudo-intelligent.” |
format | Online Article Text |
id | pubmed-6710764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-67107642019-09-04 Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal Logistic Type Laws Craciun, Anda-Mihaela Barhalescu, Mihaela Luminita Agop, Maricel Ochiuz, Lăcrămioara Comput Math Methods Med Research Article Drug release is a complex phenomenon due to the large number of interdependent side effects that occur simultaneously, involving strong nonlinear dynamics. Therefore, since their theoretical description is difficult in the classical mathematics modelling, we have built a theoretical model based on logistic type laws, validated by the correlations with the experimental data, in a special case of drug release from hydrogels. The novelty of our approach is the implementation of multifractality in logistic type laws, situation in which any chaotic system, characterized by a small number of nonlinear interactions, gets memory and, implicitly, characterization through a large number of nonlinear interactions. In other words, the complex system polymer-drug matrix becomes “pseudo-intelligent.” Hindawi 2019-08-14 /pmc/articles/PMC6710764/ /pubmed/31485257 http://dx.doi.org/10.1155/2019/4091464 Text en Copyright © 2019 Anda-Mihaela Craciun et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Craciun, Anda-Mihaela Barhalescu, Mihaela Luminita Agop, Maricel Ochiuz, Lăcrămioara Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal Logistic Type Laws |
title | Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal Logistic Type Laws |
title_full | Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal Logistic Type Laws |
title_fullStr | Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal Logistic Type Laws |
title_full_unstemmed | Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal Logistic Type Laws |
title_short | Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal Logistic Type Laws |
title_sort | theoretical modeling of long-time drug release from nitrosalicyl-imine-chitosan hydrogels through multifractal logistic type laws |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710764/ https://www.ncbi.nlm.nih.gov/pubmed/31485257 http://dx.doi.org/10.1155/2019/4091464 |
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