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Genus Miliusa: A Review of Phytochemistry and Pharmacology

BACKGROUND: Genus Miliusa (family Annonaceae), widely distributed in mainland Asia and Australia to New Guinea, has been employed in both traditional herbal uses and pharmacological medicines. Original research articles related to this genus are now available, but supportive reviews highlighting phy...

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Autor principal: The Son, Ninh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710790/
https://www.ncbi.nlm.nih.gov/pubmed/31485249
http://dx.doi.org/10.1155/2019/8314693
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author The Son, Ninh
author_facet The Son, Ninh
author_sort The Son, Ninh
collection PubMed
description BACKGROUND: Genus Miliusa (family Annonaceae), widely distributed in mainland Asia and Australia to New Guinea, has been employed in both traditional herbal uses and pharmacological medicines. Original research articles related to this genus are now available, but supportive reviews highlighting phytochemical and pharmacological aspects are now insufficient. OBJECTIVE: This account is an overview of most of the compounds isolated from this genus, along with their pharmacological evaluations. CONCLUSION: A vast amount of data showed that genus Miliusa contained various classes of secondary metabolites. Herein, more than two hundred constituents were isolated, comprising alkaloids, geranylated homogentisic acids, flavonoids, lignans, neolignans, terpenoids, acetogenins, styryls, lactones, phenolics, amides, alcohols, and furfural derivatives. Novel miliusanes and bicyclic lactones have been remarkable characteristics of Miliusa plants. Essential oils from these plants were also detected, with a high amount of β-caryophyllene. Numerous in vitro biological researches on, for example, anticancer, antifungal, antimycobacterial, anti-inflammation, and cardiac activity, especially in terms of cytotoxicity, using either isolated compounds or plant extracts, implied that Miliusa phytochemical components now set out to have a key role in pharmacological development. M. smithiae ethyl acetate extract and its flavonoid ayanin (75) inhibited the growth of MCF-7 cell line comparable with positive control ellipticine. (+)-Miliusol (72) stimulated in vivo anticancer experiment against HCT116 xenograft mouse tumor following the p21-dependent induction of cellular senescence mechanism.
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spelling pubmed-67107902019-09-04 Genus Miliusa: A Review of Phytochemistry and Pharmacology The Son, Ninh Evid Based Complement Alternat Med Review Article BACKGROUND: Genus Miliusa (family Annonaceae), widely distributed in mainland Asia and Australia to New Guinea, has been employed in both traditional herbal uses and pharmacological medicines. Original research articles related to this genus are now available, but supportive reviews highlighting phytochemical and pharmacological aspects are now insufficient. OBJECTIVE: This account is an overview of most of the compounds isolated from this genus, along with their pharmacological evaluations. CONCLUSION: A vast amount of data showed that genus Miliusa contained various classes of secondary metabolites. Herein, more than two hundred constituents were isolated, comprising alkaloids, geranylated homogentisic acids, flavonoids, lignans, neolignans, terpenoids, acetogenins, styryls, lactones, phenolics, amides, alcohols, and furfural derivatives. Novel miliusanes and bicyclic lactones have been remarkable characteristics of Miliusa plants. Essential oils from these plants were also detected, with a high amount of β-caryophyllene. Numerous in vitro biological researches on, for example, anticancer, antifungal, antimycobacterial, anti-inflammation, and cardiac activity, especially in terms of cytotoxicity, using either isolated compounds or plant extracts, implied that Miliusa phytochemical components now set out to have a key role in pharmacological development. M. smithiae ethyl acetate extract and its flavonoid ayanin (75) inhibited the growth of MCF-7 cell line comparable with positive control ellipticine. (+)-Miliusol (72) stimulated in vivo anticancer experiment against HCT116 xenograft mouse tumor following the p21-dependent induction of cellular senescence mechanism. Hindawi 2019-08-14 /pmc/articles/PMC6710790/ /pubmed/31485249 http://dx.doi.org/10.1155/2019/8314693 Text en Copyright © 2019 Ninh The Son. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
The Son, Ninh
Genus Miliusa: A Review of Phytochemistry and Pharmacology
title Genus Miliusa: A Review of Phytochemistry and Pharmacology
title_full Genus Miliusa: A Review of Phytochemistry and Pharmacology
title_fullStr Genus Miliusa: A Review of Phytochemistry and Pharmacology
title_full_unstemmed Genus Miliusa: A Review of Phytochemistry and Pharmacology
title_short Genus Miliusa: A Review of Phytochemistry and Pharmacology
title_sort genus miliusa: a review of phytochemistry and pharmacology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710790/
https://www.ncbi.nlm.nih.gov/pubmed/31485249
http://dx.doi.org/10.1155/2019/8314693
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