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Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy

Carbapenem-resistant Enterobacteriaceae (CRE) have spread rapidly around the world in the past few years, posing great challenges to human health. The plasmid-mediated horizontal transmission of carbapenem-resistance genes is the main cause of the surge in the prevalence of CRE. Therefore, the timel...

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Detalles Bibliográficos
Autores principales: Cui, Xiaoyan, Zhang, Haifang, Du, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710837/
https://www.ncbi.nlm.nih.gov/pubmed/31481937
http://dx.doi.org/10.3389/fmicb.2019.01823
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author Cui, Xiaoyan
Zhang, Haifang
Du, Hong
author_facet Cui, Xiaoyan
Zhang, Haifang
Du, Hong
author_sort Cui, Xiaoyan
collection PubMed
description Carbapenem-resistant Enterobacteriaceae (CRE) have spread rapidly around the world in the past few years, posing great challenges to human health. The plasmid-mediated horizontal transmission of carbapenem-resistance genes is the main cause of the surge in the prevalence of CRE. Therefore, the timely and accurate detection of CRE, especially carbapenemase-producing Enterobacteriaceae, is very important for the clinical prevention and treatment of these infections. A variety of methods for the rapid detection of CRE phenotypes and genotypes have been developed for use in clinical microbiology laboratories. To overcome the lack of efficient antibiotics, CRE infections are often treated with combination therapies. Moreover, novel drugs and emerging strategies appeared successively and in various stages of development. In this article, we summarized the global distribution of various carbapenemases. And we focused on summarizing and comparing the advantages and limitations of the detection methods and the therapeutic strategies of CRE primarily.
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spelling pubmed-67108372019-09-03 Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy Cui, Xiaoyan Zhang, Haifang Du, Hong Front Microbiol Microbiology Carbapenem-resistant Enterobacteriaceae (CRE) have spread rapidly around the world in the past few years, posing great challenges to human health. The plasmid-mediated horizontal transmission of carbapenem-resistance genes is the main cause of the surge in the prevalence of CRE. Therefore, the timely and accurate detection of CRE, especially carbapenemase-producing Enterobacteriaceae, is very important for the clinical prevention and treatment of these infections. A variety of methods for the rapid detection of CRE phenotypes and genotypes have been developed for use in clinical microbiology laboratories. To overcome the lack of efficient antibiotics, CRE infections are often treated with combination therapies. Moreover, novel drugs and emerging strategies appeared successively and in various stages of development. In this article, we summarized the global distribution of various carbapenemases. And we focused on summarizing and comparing the advantages and limitations of the detection methods and the therapeutic strategies of CRE primarily. Frontiers Media S.A. 2019-08-20 /pmc/articles/PMC6710837/ /pubmed/31481937 http://dx.doi.org/10.3389/fmicb.2019.01823 Text en Copyright © 2019 Cui, Zhang and Du. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Cui, Xiaoyan
Zhang, Haifang
Du, Hong
Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy
title Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy
title_full Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy
title_fullStr Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy
title_full_unstemmed Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy
title_short Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy
title_sort carbapenemases in enterobacteriaceae: detection and antimicrobial therapy
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710837/
https://www.ncbi.nlm.nih.gov/pubmed/31481937
http://dx.doi.org/10.3389/fmicb.2019.01823
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