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Interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis
Rheumatic and musculoskeletal diseases (RMDs) are chronic systemic immune/inflammatory conditions characterized by the interaction between gene predisposition, autoimmunity and environmental factors. A growing scientific interest has focused on the role of diet in RMDs, suggesting its significant co...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710844/ https://www.ncbi.nlm.nih.gov/pubmed/31462830 http://dx.doi.org/10.5114/reum.2019.86425 |
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author | Paolino, Sabrina Pacini, Greta Patanè, Massimo Alessandri, Elisa Cattelan, Francesco Goegan, Federica Pizzorni, Carmen Gotelli, Emanuele Cutolo, Maurizio |
author_facet | Paolino, Sabrina Pacini, Greta Patanè, Massimo Alessandri, Elisa Cattelan, Francesco Goegan, Federica Pizzorni, Carmen Gotelli, Emanuele Cutolo, Maurizio |
author_sort | Paolino, Sabrina |
collection | PubMed |
description | Rheumatic and musculoskeletal diseases (RMDs) are chronic systemic immune/inflammatory conditions characterized by the interaction between gene predisposition, autoimmunity and environmental factors. A growing scientific interest has focused on the role of diet in RMDs, suggesting its significant contribution to the pathogenesis and prognosis of these diseases. It is now clear that diet can directly modulate the immune response by providing a wide range of nutrients, which interfere with multiple pathways at both the gastro-intestinal and systemic level. Moreover, diet critically shapes the human gut microbiota, which is recognized to have a central role in the modulation of the immune response and in RMD pathogenesis. We hereby provide an in-depth analysis on the role of the microbiota in RMDs and on nutritional intervention as an integral part of a multidisciplinary approach. Particular attention will be given to the Mediterranean diet, as the only diet proven to support substantial benefits in RMD management. |
format | Online Article Text |
id | pubmed-6710844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie |
record_format | MEDLINE/PubMed |
spelling | pubmed-67108442019-08-28 Interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis Paolino, Sabrina Pacini, Greta Patanè, Massimo Alessandri, Elisa Cattelan, Francesco Goegan, Federica Pizzorni, Carmen Gotelli, Emanuele Cutolo, Maurizio Reumatologia Review Paper Rheumatic and musculoskeletal diseases (RMDs) are chronic systemic immune/inflammatory conditions characterized by the interaction between gene predisposition, autoimmunity and environmental factors. A growing scientific interest has focused on the role of diet in RMDs, suggesting its significant contribution to the pathogenesis and prognosis of these diseases. It is now clear that diet can directly modulate the immune response by providing a wide range of nutrients, which interfere with multiple pathways at both the gastro-intestinal and systemic level. Moreover, diet critically shapes the human gut microbiota, which is recognized to have a central role in the modulation of the immune response and in RMD pathogenesis. We hereby provide an in-depth analysis on the role of the microbiota in RMDs and on nutritional intervention as an integral part of a multidisciplinary approach. Particular attention will be given to the Mediterranean diet, as the only diet proven to support substantial benefits in RMD management. Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2019-06-28 2019 /pmc/articles/PMC6710844/ /pubmed/31462830 http://dx.doi.org/10.5114/reum.2019.86425 Text en Copyright: © 2019 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Review Paper Paolino, Sabrina Pacini, Greta Patanè, Massimo Alessandri, Elisa Cattelan, Francesco Goegan, Federica Pizzorni, Carmen Gotelli, Emanuele Cutolo, Maurizio Interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis |
title | Interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis |
title_full | Interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis |
title_fullStr | Interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis |
title_full_unstemmed | Interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis |
title_short | Interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis |
title_sort | interactions between microbiota, diet/nutrients and immune/inflammatory response in rheumatic diseases: focus on rheumatoid arthritis |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710844/ https://www.ncbi.nlm.nih.gov/pubmed/31462830 http://dx.doi.org/10.5114/reum.2019.86425 |
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