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Interleukin – 17 and Interleukin-10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases

BACKGROUND: Periimplant diseases are inflammatory diseases. Thus, the level of preinflammatory cytokines which has important role in the inflammation processes can consider as biomchemical markers for early diagnosis and prevention of periimplant diseases. The aim of this study was to determine and...

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Autores principales: Farhad, Shirin Zahra, Rezazadeh, Faeze, Mohammadi, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710915/
https://www.ncbi.nlm.nih.gov/pubmed/31516678
http://dx.doi.org/10.4103/ijpvm.IJPVM_27_19
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author Farhad, Shirin Zahra
Rezazadeh, Faeze
Mohammadi, Majid
author_facet Farhad, Shirin Zahra
Rezazadeh, Faeze
Mohammadi, Majid
author_sort Farhad, Shirin Zahra
collection PubMed
description BACKGROUND: Periimplant diseases are inflammatory diseases. Thus, the level of preinflammatory cytokines which has important role in the inflammation processes can consider as biomchemical markers for early diagnosis and prevention of periimplant diseases. The aim of this study was to determine and compare the level of interleukin (IL)-17 and IL-10 in patients with periimplant mucositis and periimplantitis. METHODS: This case--control study was conducted on 51 patients with implants which were loaded at least 1 year previously, 17 patients with periimplant mucositis, 17 patients with periimplantitis, and 17 individuals with healthy implants. After clinical examination, gingival crevicular fluid sampling was carried out by paper point number 25 for 4 min and the mean value of IL-17, IL-10 in samples was measured using enzyme linked immunosorbent assay (ELISA), least square differences (LSD) reader in laboratory. The data was analyzed using statistical software SPSS 22. Quantitative analysis was done using One-way analysis of variance (ANOVA) test and LSD past test. RESULTS: The results of analysis showed that there was a significant difference in the mean value of IL-17 and IL-10 between the three study groups (P < 0.001). Individuals with healthy implants showed a significant lower level of IL-17 than patients with periimplantitis (P = 0.001) and for patients with periimplantitis, the level of IL-17 was significantly lower than that of patients with periimplant mucositis (P < 0.001) and IL-10 level was significantly lower in mucositis than periimplantitis (P < 0.001). CONCLUSIONS: The level of IL-17 and IL-10 increased in patients with periimplant compared to individuals with healthy periimplant tissues and the results showed that the highest concentrations of IL-17 and IL-10 were observed in patients with periimplant mucositis and periimplantitis, respectively.
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spelling pubmed-67109152019-09-12 Interleukin – 17 and Interleukin-10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases Farhad, Shirin Zahra Rezazadeh, Faeze Mohammadi, Majid Int J Prev Med Original Article BACKGROUND: Periimplant diseases are inflammatory diseases. Thus, the level of preinflammatory cytokines which has important role in the inflammation processes can consider as biomchemical markers for early diagnosis and prevention of periimplant diseases. The aim of this study was to determine and compare the level of interleukin (IL)-17 and IL-10 in patients with periimplant mucositis and periimplantitis. METHODS: This case--control study was conducted on 51 patients with implants which were loaded at least 1 year previously, 17 patients with periimplant mucositis, 17 patients with periimplantitis, and 17 individuals with healthy implants. After clinical examination, gingival crevicular fluid sampling was carried out by paper point number 25 for 4 min and the mean value of IL-17, IL-10 in samples was measured using enzyme linked immunosorbent assay (ELISA), least square differences (LSD) reader in laboratory. The data was analyzed using statistical software SPSS 22. Quantitative analysis was done using One-way analysis of variance (ANOVA) test and LSD past test. RESULTS: The results of analysis showed that there was a significant difference in the mean value of IL-17 and IL-10 between the three study groups (P < 0.001). Individuals with healthy implants showed a significant lower level of IL-17 than patients with periimplantitis (P = 0.001) and for patients with periimplantitis, the level of IL-17 was significantly lower than that of patients with periimplant mucositis (P < 0.001) and IL-10 level was significantly lower in mucositis than periimplantitis (P < 0.001). CONCLUSIONS: The level of IL-17 and IL-10 increased in patients with periimplant compared to individuals with healthy periimplant tissues and the results showed that the highest concentrations of IL-17 and IL-10 were observed in patients with periimplant mucositis and periimplantitis, respectively. Wolters Kluwer - Medknow 2019-08-12 /pmc/articles/PMC6710915/ /pubmed/31516678 http://dx.doi.org/10.4103/ijpvm.IJPVM_27_19 Text en Copyright: © 2019 International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Farhad, Shirin Zahra
Rezazadeh, Faeze
Mohammadi, Majid
Interleukin – 17 and Interleukin-10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases
title Interleukin – 17 and Interleukin-10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases
title_full Interleukin – 17 and Interleukin-10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases
title_fullStr Interleukin – 17 and Interleukin-10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases
title_full_unstemmed Interleukin – 17 and Interleukin-10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases
title_short Interleukin – 17 and Interleukin-10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases
title_sort interleukin – 17 and interleukin-10 as inflammatory and prevention biomarkers in periimplant diseases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710915/
https://www.ncbi.nlm.nih.gov/pubmed/31516678
http://dx.doi.org/10.4103/ijpvm.IJPVM_27_19
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