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Advanced Parental Age and Risk of Positive Autism Spectrum Disorders Screening
BACKGROUND: Autism Spectrum Disorder (ASD) is a life -long neurodevelopmental disorder and significantly influences the quality of life in children. The screening of ASD in children aged between 16-30 months to early detection and early intervention for better prognosis. METHODS: This cross-sectiona...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710919/ https://www.ncbi.nlm.nih.gov/pubmed/31516676 http://dx.doi.org/10.4103/ijpvm.IJPVM_25_19 |
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author | Manzouri, Leila Yousefian, Sepideh Keshtkari, Ali Hashemi, Nazir |
author_facet | Manzouri, Leila Yousefian, Sepideh Keshtkari, Ali Hashemi, Nazir |
author_sort | Manzouri, Leila |
collection | PubMed |
description | BACKGROUND: Autism Spectrum Disorder (ASD) is a life -long neurodevelopmental disorder and significantly influences the quality of life in children. The screening of ASD in children aged between 16-30 months to early detection and early intervention for better prognosis. METHODS: This cross-sectional study was conducted in the southwest of Iran (Yasuj) with dominant Lore ethnicity in 2017. A total of 1504 mother- child pairs with children aged between 16-30 months were selected through simple random sampling from the integrated national health system as the framework. ASD screening was implemented using the Modified checklist for autism in toddlers- revised, with follow-up interview (M-CHAT-R/F). Demographic data such as sex of children, and parental age at their time of pregnancy were collected for all children. RESULTS: Risk of ASD was low, moderate and high in 1447 (96.2%), 54 (3.6%) and 3 (0.2%) in screening, respectively. The estimated rate of ASD prevalence was 80 per 10000 (12 out of 1504) or 1 in 125. Mother's age ≥35 (P value = 0.002, OR = 11.65, CI(95%): 2.49-54.35) and father's age ≥40 (P value = 0.0001, OR = 19.64, CI(95%): 4.89-78.82) were predicting factors of ASD in toddlers aged 16-30 months. CONCLUSIONS: Given that, increasing the age of marriage in Iran and recent trend towards delayed childbearing; children born to older parents are at a higher risk for having ASD. So, increasing the public awareness is necessary. |
format | Online Article Text |
id | pubmed-6710919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-67109192019-09-12 Advanced Parental Age and Risk of Positive Autism Spectrum Disorders Screening Manzouri, Leila Yousefian, Sepideh Keshtkari, Ali Hashemi, Nazir Int J Prev Med Original Article BACKGROUND: Autism Spectrum Disorder (ASD) is a life -long neurodevelopmental disorder and significantly influences the quality of life in children. The screening of ASD in children aged between 16-30 months to early detection and early intervention for better prognosis. METHODS: This cross-sectional study was conducted in the southwest of Iran (Yasuj) with dominant Lore ethnicity in 2017. A total of 1504 mother- child pairs with children aged between 16-30 months were selected through simple random sampling from the integrated national health system as the framework. ASD screening was implemented using the Modified checklist for autism in toddlers- revised, with follow-up interview (M-CHAT-R/F). Demographic data such as sex of children, and parental age at their time of pregnancy were collected for all children. RESULTS: Risk of ASD was low, moderate and high in 1447 (96.2%), 54 (3.6%) and 3 (0.2%) in screening, respectively. The estimated rate of ASD prevalence was 80 per 10000 (12 out of 1504) or 1 in 125. Mother's age ≥35 (P value = 0.002, OR = 11.65, CI(95%): 2.49-54.35) and father's age ≥40 (P value = 0.0001, OR = 19.64, CI(95%): 4.89-78.82) were predicting factors of ASD in toddlers aged 16-30 months. CONCLUSIONS: Given that, increasing the age of marriage in Iran and recent trend towards delayed childbearing; children born to older parents are at a higher risk for having ASD. So, increasing the public awareness is necessary. Wolters Kluwer - Medknow 2019-08-12 /pmc/articles/PMC6710919/ /pubmed/31516676 http://dx.doi.org/10.4103/ijpvm.IJPVM_25_19 Text en Copyright: © 2019 International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Manzouri, Leila Yousefian, Sepideh Keshtkari, Ali Hashemi, Nazir Advanced Parental Age and Risk of Positive Autism Spectrum Disorders Screening |
title | Advanced Parental Age and Risk of Positive Autism Spectrum Disorders Screening |
title_full | Advanced Parental Age and Risk of Positive Autism Spectrum Disorders Screening |
title_fullStr | Advanced Parental Age and Risk of Positive Autism Spectrum Disorders Screening |
title_full_unstemmed | Advanced Parental Age and Risk of Positive Autism Spectrum Disorders Screening |
title_short | Advanced Parental Age and Risk of Positive Autism Spectrum Disorders Screening |
title_sort | advanced parental age and risk of positive autism spectrum disorders screening |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710919/ https://www.ncbi.nlm.nih.gov/pubmed/31516676 http://dx.doi.org/10.4103/ijpvm.IJPVM_25_19 |
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