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Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy

AIM: To compare intraocular pressure and anterior chamber angle changes between pilocarpine and laser peripheral iridotomy in primary angle closure. MATERIALS AND METHODS: In this clinical trial study, 34 eyes of 29 patients with primary angle-closure were prospectively enrolled between November 201...

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Autores principales: Yunard, Ardiella, Oktariana, Virna D, Artini, Widya, Prihartono, Joedo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710935/
https://www.ncbi.nlm.nih.gov/pubmed/31496559
http://dx.doi.org/10.5005/jp-journals-10078-1245
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author Yunard, Ardiella
Oktariana, Virna D
Artini, Widya
Prihartono, Joedo
author_facet Yunard, Ardiella
Oktariana, Virna D
Artini, Widya
Prihartono, Joedo
author_sort Yunard, Ardiella
collection PubMed
description AIM: To compare intraocular pressure and anterior chamber angle changes between pilocarpine and laser peripheral iridotomy in primary angle closure. MATERIALS AND METHODS: In this clinical trial study, 34 eyes of 29 patients with primary angle-closure were prospectively enrolled between November 2015 and February 2016. Intraocular pressure and anterior segment optical coherence tomography were performed at three separate times: on the initial conditions, 3–5 days of administration of topical pilocarpine 2%, and 1 week after laser iridotomy. Anterior chamber angle parameters were the angle opening distance (AOD) and trabecular–iris space area (TISA). RESULTS: The intraocular pressure reduction following pilocarpine administration was significant compared to laser iridotomy: 3.9 mm Hg (−32.5 to 0.20) vs 1.8 mm Hg (−33.5 to 2.30) (p = 0.002). Meanwhile, the increment of angle parameters following laser iridotomy was significant compared to pilocarpine. The AOD750 increment of both nasal and temporal quadrant following laser iridotomy was significant compared to pilocarpine: 0.13 mm (−0.27 to 0.28) vs 0.05 mm (−0.35 to 0.29) (p = 0.003) and 0.12 mm (−0.10 to 0.34) vs 0.04 mm (−0.27 to 0.19) (p = 0.002), respectively. The TISA750 increment of both nasal and temporal quadrant following laser iridotomy was also significant compared to pilocarpine: 0.05 mm(2) (−0.06 to 0.20) vs 0.02 mm(2) (−0.12 to 0.13) (p = 0.023) and 0.04 mm(2) (−0.04 to 0.17) vs 0.01 mm(2) (−0.14 to 0.18) (p = 0.012), respectively. CONCLUSION: Laser peripheral iridotomy widens the angle greater than topical pilocarpine, but topical pilocarpine lowers the intraocular pressure greater than laser iridotomy. These data suggest that pilocarpine has another mechanism to decrease the intraocular pressure in primary angle-closure, besides widening the angle. HOW TO CITE THIS ARTICLE: Yunard A, Oktariana VD, et al. Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy. J Curr Glaucoma Pract 2019;13(1):32–36.
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spelling pubmed-67109352019-09-06 Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy Yunard, Ardiella Oktariana, Virna D Artini, Widya Prihartono, Joedo J Curr Glaucoma Pract Research Article AIM: To compare intraocular pressure and anterior chamber angle changes between pilocarpine and laser peripheral iridotomy in primary angle closure. MATERIALS AND METHODS: In this clinical trial study, 34 eyes of 29 patients with primary angle-closure were prospectively enrolled between November 2015 and February 2016. Intraocular pressure and anterior segment optical coherence tomography were performed at three separate times: on the initial conditions, 3–5 days of administration of topical pilocarpine 2%, and 1 week after laser iridotomy. Anterior chamber angle parameters were the angle opening distance (AOD) and trabecular–iris space area (TISA). RESULTS: The intraocular pressure reduction following pilocarpine administration was significant compared to laser iridotomy: 3.9 mm Hg (−32.5 to 0.20) vs 1.8 mm Hg (−33.5 to 2.30) (p = 0.002). Meanwhile, the increment of angle parameters following laser iridotomy was significant compared to pilocarpine. The AOD750 increment of both nasal and temporal quadrant following laser iridotomy was significant compared to pilocarpine: 0.13 mm (−0.27 to 0.28) vs 0.05 mm (−0.35 to 0.29) (p = 0.003) and 0.12 mm (−0.10 to 0.34) vs 0.04 mm (−0.27 to 0.19) (p = 0.002), respectively. The TISA750 increment of both nasal and temporal quadrant following laser iridotomy was also significant compared to pilocarpine: 0.05 mm(2) (−0.06 to 0.20) vs 0.02 mm(2) (−0.12 to 0.13) (p = 0.023) and 0.04 mm(2) (−0.04 to 0.17) vs 0.01 mm(2) (−0.14 to 0.18) (p = 0.012), respectively. CONCLUSION: Laser peripheral iridotomy widens the angle greater than topical pilocarpine, but topical pilocarpine lowers the intraocular pressure greater than laser iridotomy. These data suggest that pilocarpine has another mechanism to decrease the intraocular pressure in primary angle-closure, besides widening the angle. HOW TO CITE THIS ARTICLE: Yunard A, Oktariana VD, et al. Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy. J Curr Glaucoma Pract 2019;13(1):32–36. Jaypee Brothers Medical Publishers 2019 /pmc/articles/PMC6710935/ /pubmed/31496559 http://dx.doi.org/10.5005/jp-journals-10078-1245 Text en Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd. This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Research Article
Yunard, Ardiella
Oktariana, Virna D
Artini, Widya
Prihartono, Joedo
Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy
title Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy
title_full Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy
title_fullStr Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy
title_full_unstemmed Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy
title_short Comparison of Intraocular Pressure and Anterior Chamber Angle Changes between Pilocarpine and Laser Peripheral Iridotomy
title_sort comparison of intraocular pressure and anterior chamber angle changes between pilocarpine and laser peripheral iridotomy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710935/
https://www.ncbi.nlm.nih.gov/pubmed/31496559
http://dx.doi.org/10.5005/jp-journals-10078-1245
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