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Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease. We investigated whether serum inflammatory markers, C-reactive protein (CRP), leptin, and nutritional status (assessed by measurement of serum levels of prealbumin and anthropometry) correlated with COPD sev...

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Autores principales: Arora, Sneh, Madan, Karan, Mohan, Anant, Kalaivani, Mani, Guleria, Randeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710956/
https://www.ncbi.nlm.nih.gov/pubmed/31464210
http://dx.doi.org/10.4103/lungindia.lungindia_494_18
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author Arora, Sneh
Madan, Karan
Mohan, Anant
Kalaivani, Mani
Guleria, Randeep
author_facet Arora, Sneh
Madan, Karan
Mohan, Anant
Kalaivani, Mani
Guleria, Randeep
author_sort Arora, Sneh
collection PubMed
description BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease. We investigated whether serum inflammatory markers, C-reactive protein (CRP), leptin, and nutritional status (assessed by measurement of serum levels of prealbumin and anthropometry) correlated with COPD severity. MATERIALS AND METHODS: One-hundred and two COPD patients (mean age 56.94 ± 10.95 years) were recruited and classified into severity categories based on the GOLD guidelines. Serum concentrations of CRP, prealbumin, and leptin were measured. Anthropometry included body mass index (BMI), mid-upper arm circumference (MUAC), and sum of four skinfold thicknesses (triceps, biceps, suprailiac, and subscapular). RESULTS: Twenty-one patients had moderate, 44 had severe, and 37 had very severe COPD. Levels of CRP (mg/dl) (mean ± standard error [SE]) in moderate, severe, and very severe COPD were 0.60 ± 0.096, 2.16 ± 0.39, and 4.15 ± 0.463, respectively. Levels of prealbumin (mg/dl) (mean ± SE) in moderate, severe, and very severe COPD were 15.7 3 ± 0.92, 10.95 ± 0.85, and 11.15 ± 0.79 mg/dl, respectively. Levels of leptin (ng/ml) (mean ± SE) in moderate, severe, and very severe COPD were 13.81 ± 3.88, 8.45 ± 2.25, and 4.40 ± 1.06, respectively. BMI values in the three groups were 23.44 ± 1.16 kg/m(2), 20.33 ± 0.62 kg/m(2), and 18.86 ± 0.52 kg/m(2), respectively. Sum of four skinfold thickness and MUAC was significantly reduced in very severe group as compared to moderate and severe group. Very severe COPD patients had a significantly lower leptin, BMI, and 6-min walk test. Serum CRP was significantly higher in very severe COPD. CONCLUSION: Patients with increasing severity of COPD had a significantly greater serum inflammatory marker level and poorer nutritional status.
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spelling pubmed-67109562019-09-12 Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease Arora, Sneh Madan, Karan Mohan, Anant Kalaivani, Mani Guleria, Randeep Lung India Original Article BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease. We investigated whether serum inflammatory markers, C-reactive protein (CRP), leptin, and nutritional status (assessed by measurement of serum levels of prealbumin and anthropometry) correlated with COPD severity. MATERIALS AND METHODS: One-hundred and two COPD patients (mean age 56.94 ± 10.95 years) were recruited and classified into severity categories based on the GOLD guidelines. Serum concentrations of CRP, prealbumin, and leptin were measured. Anthropometry included body mass index (BMI), mid-upper arm circumference (MUAC), and sum of four skinfold thicknesses (triceps, biceps, suprailiac, and subscapular). RESULTS: Twenty-one patients had moderate, 44 had severe, and 37 had very severe COPD. Levels of CRP (mg/dl) (mean ± standard error [SE]) in moderate, severe, and very severe COPD were 0.60 ± 0.096, 2.16 ± 0.39, and 4.15 ± 0.463, respectively. Levels of prealbumin (mg/dl) (mean ± SE) in moderate, severe, and very severe COPD were 15.7 3 ± 0.92, 10.95 ± 0.85, and 11.15 ± 0.79 mg/dl, respectively. Levels of leptin (ng/ml) (mean ± SE) in moderate, severe, and very severe COPD were 13.81 ± 3.88, 8.45 ± 2.25, and 4.40 ± 1.06, respectively. BMI values in the three groups were 23.44 ± 1.16 kg/m(2), 20.33 ± 0.62 kg/m(2), and 18.86 ± 0.52 kg/m(2), respectively. Sum of four skinfold thickness and MUAC was significantly reduced in very severe group as compared to moderate and severe group. Very severe COPD patients had a significantly lower leptin, BMI, and 6-min walk test. Serum CRP was significantly higher in very severe COPD. CONCLUSION: Patients with increasing severity of COPD had a significantly greater serum inflammatory marker level and poorer nutritional status. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6710956/ /pubmed/31464210 http://dx.doi.org/10.4103/lungindia.lungindia_494_18 Text en Copyright: © 2019 Indian Chest Society http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Arora, Sneh
Madan, Karan
Mohan, Anant
Kalaivani, Mani
Guleria, Randeep
Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease
title Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease
title_full Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease
title_fullStr Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease
title_full_unstemmed Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease
title_short Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease
title_sort serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710956/
https://www.ncbi.nlm.nih.gov/pubmed/31464210
http://dx.doi.org/10.4103/lungindia.lungindia_494_18
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