Age-related metabolic changes limit efficacy of deoxynucleoside-based therapy in thymidine kinase 2-deficient mice

BACKGROUND: Thymidine kinase 2 (TK2) catalyses the phosphorylation of deoxythymidine (dThd) and deoxycytidine (dCtd) within mitochondria. TK2 deficiency leads to mtDNA depletion or accumulation of multiple deletions. In patients, TK2 mutations typically manifest as a rapidly progressive myopathy wit...

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Detalles Bibliográficos
Autores principales: Blázquez-Bermejo, Cora, Molina-Granada, David, Vila-Julià, Ferran, Jiménez-Heis, Daniel, Zhou, Xiaoshan, Torres-Torronteras, Javier, Karlsson, Anna, Martí, Ramon, Cámara, Yolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711114/
https://www.ncbi.nlm.nih.gov/pubmed/31351931
http://dx.doi.org/10.1016/j.ebiom.2019.07.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711114/
https://www.ncbi.nlm.nih.gov/pubmed/31351931
http://dx.doi.org/10.1016/j.ebiom.2019.07.042

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