Novel 2-phenoxypyrido[3,2-b]pyrazin-3(4H)-one derivatives as potent and selective aldose reductase inhibitors with antioxidant activity

To develop multifunctional aldose reductase (AKR1B1) inhibitors for anti-diabetic complications, a novel series of 2-phenoxypyrido[3,2-b]pyrazin-3(4H)-one derivatives were designed and synthesised. Most of the derivatives were found to be potent and selective against AKR1B1, and 2-(7-chloro-2-(3,5-d...

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Detalles Bibliográficos
Autores principales: Hao, Xin, Qi, Gang, Ma, Hongxing, Zhu, Changjin, Han, Zhongfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711126/
https://www.ncbi.nlm.nih.gov/pubmed/31347930
http://dx.doi.org/10.1080/14756366.2019.1643336

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