Decision Tool for Herpes B Virus Antiviral Prophylaxis after Macaque-Related Injuries in Research Laboratory Workers

Macaque-related injuries among primate workers can lead to a potentially fatal B virus encephalomyelitis. We describe a decision tool for evaluating the need for antiviral postexposure prophylaxis and provide a retrospective review of the injuries assessed in our center after its implementation in 2...

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Autores principales: Barkati, Sapha, Taher, Hashim Ba, Beauchamp, Elizabeth, Yansouni, Cédric P., Ward, Brian J., Libman, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Online Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711206/
https://www.ncbi.nlm.nih.gov/pubmed/31441751
http://dx.doi.org/10.3201/eid2509.190045
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author Barkati, Sapha
Taher, Hashim Ba
Beauchamp, Elizabeth
Yansouni, Cédric P.
Ward, Brian J.
Libman, Michael D.
author_facet Barkati, Sapha
Taher, Hashim Ba
Beauchamp, Elizabeth
Yansouni, Cédric P.
Ward, Brian J.
Libman, Michael D.
author_sort Barkati, Sapha
collection PubMed
description Macaque-related injuries among primate workers can lead to a potentially fatal B virus encephalomyelitis. We describe a decision tool for evaluating the need for antiviral postexposure prophylaxis and provide a retrospective review of the injuries assessed in our center after its implementation in 2010. Among the injuries studied (n = 251), 40.6% were categorized as high-risk (prophylaxis recommended), 44.2% moderate-risk (consider prophylaxis), and 15.1% low-risk (prophylaxis not recommended). Ten percent of low-risk and 98% of high-risk injuries received prophylaxis (p<0.001). Compared with using universal postexposure prophylaxis, using a decision tool can lead to a standardization of practice and a reduction in prescriptions for antiviral medication.
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spelling pubmed-67112062019-09-04 Decision Tool for Herpes B Virus Antiviral Prophylaxis after Macaque-Related Injuries in Research Laboratory Workers Barkati, Sapha Taher, Hashim Ba Beauchamp, Elizabeth Yansouni, Cédric P. Ward, Brian J. Libman, Michael D. Emerg Infect Dis Online Report Macaque-related injuries among primate workers can lead to a potentially fatal B virus encephalomyelitis. We describe a decision tool for evaluating the need for antiviral postexposure prophylaxis and provide a retrospective review of the injuries assessed in our center after its implementation in 2010. Among the injuries studied (n = 251), 40.6% were categorized as high-risk (prophylaxis recommended), 44.2% moderate-risk (consider prophylaxis), and 15.1% low-risk (prophylaxis not recommended). Ten percent of low-risk and 98% of high-risk injuries received prophylaxis (p<0.001). Compared with using universal postexposure prophylaxis, using a decision tool can lead to a standardization of practice and a reduction in prescriptions for antiviral medication. Centers for Disease Control and Prevention 2019-09 /pmc/articles/PMC6711206/ /pubmed/31441751 http://dx.doi.org/10.3201/eid2509.190045 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Online Report
Barkati, Sapha
Taher, Hashim Ba
Beauchamp, Elizabeth
Yansouni, Cédric P.
Ward, Brian J.
Libman, Michael D.
Decision Tool for Herpes B Virus Antiviral Prophylaxis after Macaque-Related Injuries in Research Laboratory Workers
title Decision Tool for Herpes B Virus Antiviral Prophylaxis after Macaque-Related Injuries in Research Laboratory Workers
title_full Decision Tool for Herpes B Virus Antiviral Prophylaxis after Macaque-Related Injuries in Research Laboratory Workers
title_fullStr Decision Tool for Herpes B Virus Antiviral Prophylaxis after Macaque-Related Injuries in Research Laboratory Workers
title_full_unstemmed Decision Tool for Herpes B Virus Antiviral Prophylaxis after Macaque-Related Injuries in Research Laboratory Workers
title_short Decision Tool for Herpes B Virus Antiviral Prophylaxis after Macaque-Related Injuries in Research Laboratory Workers
title_sort decision tool for herpes b virus antiviral prophylaxis after macaque-related injuries in research laboratory workers
topic Online Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711206/
https://www.ncbi.nlm.nih.gov/pubmed/31441751
http://dx.doi.org/10.3201/eid2509.190045
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