Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients

We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole–resistant Aspergillus fumigatus isolate and the other a Rhizomucor–A. fumigatus co-infection. Such patients probably require surveillance by galactomanna...

Descripción completa

Detalles Bibliográficos
Autores principales: Bellanger, Anne-Pauline, Berceanu, Ana, Scherer, Emeline, Desbrosses, Yohan, Daguindau, Etienne, Rocchi, Steffi, Millon, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711214/
https://www.ncbi.nlm.nih.gov/pubmed/31441760
http://dx.doi.org/10.3201/eid2509.190598
Descripción
Sumario:We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole–resistant Aspergillus fumigatus isolate and the other a Rhizomucor–A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.

Ejemplares similares