Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients

We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole–resistant Aspergillus fumigatus isolate and the other a Rhizomucor–A. fumigatus co-infection. Such patients probably require surveillance by galactomanna...

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Autores principales: Bellanger, Anne-Pauline, Berceanu, Ana, Scherer, Emeline, Desbrosses, Yohan, Daguindau, Etienne, Rocchi, Steffi, Millon, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711214/
https://www.ncbi.nlm.nih.gov/pubmed/31441760
http://dx.doi.org/10.3201/eid2509.190598
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author Bellanger, Anne-Pauline
Berceanu, Ana
Scherer, Emeline
Desbrosses, Yohan
Daguindau, Etienne
Rocchi, Steffi
Millon, Laurence
author_facet Bellanger, Anne-Pauline
Berceanu, Ana
Scherer, Emeline
Desbrosses, Yohan
Daguindau, Etienne
Rocchi, Steffi
Millon, Laurence
author_sort Bellanger, Anne-Pauline
collection PubMed
description We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole–resistant Aspergillus fumigatus isolate and the other a Rhizomucor–A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.
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spelling pubmed-67112142019-09-04 Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients Bellanger, Anne-Pauline Berceanu, Ana Scherer, Emeline Desbrosses, Yohan Daguindau, Etienne Rocchi, Steffi Millon, Laurence Emerg Infect Dis Research Letter We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole–resistant Aspergillus fumigatus isolate and the other a Rhizomucor–A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi. Centers for Disease Control and Prevention 2019-09 /pmc/articles/PMC6711214/ /pubmed/31441760 http://dx.doi.org/10.3201/eid2509.190598 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Bellanger, Anne-Pauline
Berceanu, Ana
Scherer, Emeline
Desbrosses, Yohan
Daguindau, Etienne
Rocchi, Steffi
Millon, Laurence
Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients
title Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients
title_full Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients
title_fullStr Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients
title_full_unstemmed Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients
title_short Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients
title_sort invasive fungal disease, isavuconazole treatment failure, and death in acute myeloid leukemia patients
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711214/
https://www.ncbi.nlm.nih.gov/pubmed/31441760
http://dx.doi.org/10.3201/eid2509.190598
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