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Stereotactic ablative body radiotherapy (SABR) for inoperable, chemorefractory retroperitoneal lymph node relapse from non seminomatous germ cell tumour of testis: a case report

We describe a case of non-seminomatous germ cell tumour (NSGCT) of the testis with oligorecurrence in para-aortic nodal mass, which was inoperable and chemorefractory. Conventionally fractionated radiotherapy in this setting is generally believed to achieve poor results, because the dose is limited...

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Autores principales: Gulia, Abhishek, Anand, Anil Kumar, Punnakal, Anirudh Urumi, Kumar, Amit, Patro, Ch Kartikeswar, Bansal, Anil Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711267/
https://www.ncbi.nlm.nih.gov/pubmed/31489207
http://dx.doi.org/10.1259/bjrcr.20160114
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author Gulia, Abhishek
Anand, Anil Kumar
Punnakal, Anirudh Urumi
Kumar, Amit
Patro, Ch Kartikeswar
Bansal, Anil Kumar
author_facet Gulia, Abhishek
Anand, Anil Kumar
Punnakal, Anirudh Urumi
Kumar, Amit
Patro, Ch Kartikeswar
Bansal, Anil Kumar
author_sort Gulia, Abhishek
collection PubMed
description We describe a case of non-seminomatous germ cell tumour (NSGCT) of the testis with oligorecurrence in para-aortic nodal mass, which was inoperable and chemorefractory. Conventionally fractionated radiotherapy in this setting is generally believed to achieve poor results, because the dose is limited by the tolerance of surrounding normal tissues. Use of stereotactic ablative body radiotherapy (SABR) for para-aortic nodal recurrence from a few sites has been reported; its application in NSGCT has not been described in literature to our knowledge. SABR allowed us to deliver highly precise, ablative dose of radiation to the recurrent para-aortic nodal mass with long-term disease control (more than 6 years). The ablative dose delivered with SABR proved to be effective in NSGCT, traditionally considered radioresistant. While, in the present case SABR was delivered due to the inoperability of the lesion, further data on its successful use in NSGCT recurrences is warranted.
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spelling pubmed-67112672019-09-05 Stereotactic ablative body radiotherapy (SABR) for inoperable, chemorefractory retroperitoneal lymph node relapse from non seminomatous germ cell tumour of testis: a case report Gulia, Abhishek Anand, Anil Kumar Punnakal, Anirudh Urumi Kumar, Amit Patro, Ch Kartikeswar Bansal, Anil Kumar BJR Case Rep Case Report We describe a case of non-seminomatous germ cell tumour (NSGCT) of the testis with oligorecurrence in para-aortic nodal mass, which was inoperable and chemorefractory. Conventionally fractionated radiotherapy in this setting is generally believed to achieve poor results, because the dose is limited by the tolerance of surrounding normal tissues. Use of stereotactic ablative body radiotherapy (SABR) for para-aortic nodal recurrence from a few sites has been reported; its application in NSGCT has not been described in literature to our knowledge. SABR allowed us to deliver highly precise, ablative dose of radiation to the recurrent para-aortic nodal mass with long-term disease control (more than 6 years). The ablative dose delivered with SABR proved to be effective in NSGCT, traditionally considered radioresistant. While, in the present case SABR was delivered due to the inoperability of the lesion, further data on its successful use in NSGCT recurrences is warranted. The British Institute of Radiology. 2018-03-14 /pmc/articles/PMC6711267/ /pubmed/31489207 http://dx.doi.org/10.1259/bjrcr.20160114 Text en © 2018 The Authors. Published by the British Institute of Radiology http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Report
Gulia, Abhishek
Anand, Anil Kumar
Punnakal, Anirudh Urumi
Kumar, Amit
Patro, Ch Kartikeswar
Bansal, Anil Kumar
Stereotactic ablative body radiotherapy (SABR) for inoperable, chemorefractory retroperitoneal lymph node relapse from non seminomatous germ cell tumour of testis: a case report
title Stereotactic ablative body radiotherapy (SABR) for inoperable, chemorefractory retroperitoneal lymph node relapse from non seminomatous germ cell tumour of testis: a case report
title_full Stereotactic ablative body radiotherapy (SABR) for inoperable, chemorefractory retroperitoneal lymph node relapse from non seminomatous germ cell tumour of testis: a case report
title_fullStr Stereotactic ablative body radiotherapy (SABR) for inoperable, chemorefractory retroperitoneal lymph node relapse from non seminomatous germ cell tumour of testis: a case report
title_full_unstemmed Stereotactic ablative body radiotherapy (SABR) for inoperable, chemorefractory retroperitoneal lymph node relapse from non seminomatous germ cell tumour of testis: a case report
title_short Stereotactic ablative body radiotherapy (SABR) for inoperable, chemorefractory retroperitoneal lymph node relapse from non seminomatous germ cell tumour of testis: a case report
title_sort stereotactic ablative body radiotherapy (sabr) for inoperable, chemorefractory retroperitoneal lymph node relapse from non seminomatous germ cell tumour of testis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711267/
https://www.ncbi.nlm.nih.gov/pubmed/31489207
http://dx.doi.org/10.1259/bjrcr.20160114
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