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Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity
Background: Designation of disease activity is serious for the management of systemic lupus erythematosus (SLE). Serum level of β2 microglobulin (β2M) may be associated with illness activity in SLE disease. Since the role of β2M for assessing of illness activity in SLE is not completely clear, the c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
EDP Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711321/ https://www.ncbi.nlm.nih.gov/pubmed/31453797 http://dx.doi.org/10.1051/bmdcn/2019090316 |
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author | Aghdashi, Miramir Salami, Simak Nezhadisalami, Ahmad |
author_facet | Aghdashi, Miramir Salami, Simak Nezhadisalami, Ahmad |
author_sort | Aghdashi, Miramir |
collection | PubMed |
description | Background: Designation of disease activity is serious for the management of systemic lupus erythematosus (SLE). Serum level of β2 microglobulin (β2M) may be associated with illness activity in SLE disease. Since the role of β2M for assessing of illness activity in SLE is not completely clear, the current study aimed to discern evaluation of β2M in patients with SLE and its correlation with sickness activity. Materials and Methods: In this case-control study, 50 patients with SLE disease and 25 healthy individuals were selected in Imam Khomeini Hospital in central of Urmia. Blood samples were collected safely from patients, serum was removed, and β2M measured using an ELISA method. The results for other parameters including C reactive protein, C3, C4, anti dsDNA and erythrocyte sedimentation rate were obtained from patients’ medical record. Data analyzed using appropriate statistical tests including Mann-Whitney U test, Independent f-test, Kruskal-Wallis, and Spearman used for analysis of data. Results: In the current study, a significant difference was seen between two groups in terms of β2M (p < 0.001). Remarkable correlation was seen between the level of β2M with disease activity (p < 0.001). Furthermore, there are significant relevancy between the level of β2M with 24-hour urine protein, ESR, disease activity score, and CRP (p < 0.05). Conclusion: The results revealed that serum amount of β2M in SLE patients is higher compared to healthy ones, which is significantly correlated to score of illness activity, CRP, and ESR in patients with SLE disease. Hence β2M might be an excellent serological marker helping the prediction of sickness activity and inflammation in SLE patients. |
format | Online Article Text |
id | pubmed-6711321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | EDP Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-67113212019-09-12 Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity Aghdashi, Miramir Salami, Simak Nezhadisalami, Ahmad Biomedicine (Taipei) Original Article Background: Designation of disease activity is serious for the management of systemic lupus erythematosus (SLE). Serum level of β2 microglobulin (β2M) may be associated with illness activity in SLE disease. Since the role of β2M for assessing of illness activity in SLE is not completely clear, the current study aimed to discern evaluation of β2M in patients with SLE and its correlation with sickness activity. Materials and Methods: In this case-control study, 50 patients with SLE disease and 25 healthy individuals were selected in Imam Khomeini Hospital in central of Urmia. Blood samples were collected safely from patients, serum was removed, and β2M measured using an ELISA method. The results for other parameters including C reactive protein, C3, C4, anti dsDNA and erythrocyte sedimentation rate were obtained from patients’ medical record. Data analyzed using appropriate statistical tests including Mann-Whitney U test, Independent f-test, Kruskal-Wallis, and Spearman used for analysis of data. Results: In the current study, a significant difference was seen between two groups in terms of β2M (p < 0.001). Remarkable correlation was seen between the level of β2M with disease activity (p < 0.001). Furthermore, there are significant relevancy between the level of β2M with 24-hour urine protein, ESR, disease activity score, and CRP (p < 0.05). Conclusion: The results revealed that serum amount of β2M in SLE patients is higher compared to healthy ones, which is significantly correlated to score of illness activity, CRP, and ESR in patients with SLE disease. Hence β2M might be an excellent serological marker helping the prediction of sickness activity and inflammation in SLE patients. EDP Sciences 2019-08-27 /pmc/articles/PMC6711321/ /pubmed/31453797 http://dx.doi.org/10.1051/bmdcn/2019090316 Text en © Author(s) 2019. This article is published with open access by China Medical University Open Access This article is distributed under terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited. |
spellingShingle | Original Article Aghdashi, Miramir Salami, Simak Nezhadisalami, Ahmad Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity |
title | Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity |
title_full | Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity |
title_fullStr | Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity |
title_full_unstemmed | Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity |
title_short | Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity |
title_sort | evaluation of the serum β2 microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711321/ https://www.ncbi.nlm.nih.gov/pubmed/31453797 http://dx.doi.org/10.1051/bmdcn/2019090316 |
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