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Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives
The development of efficacious and safe drugs for the treatment of neurological diseases related to glutamate toxicity has been a focus in neuropharmacological research. Specifically, discovering antagonists to modulate the activity and kinetics of AMPA receptors, which are the fastest ligand-gated...
Autores principales: | Qneibi, Mohammad, Hamed, Othman, Natsheh, Abdel-Razzak, Fares, Oswa, Jaradat, Nidal, Emwas, Nour, AbuHasan, Qais, Al-Kerm, Rana, Al-Kerm, Rola |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711591/ https://www.ncbi.nlm.nih.gov/pubmed/31454362 http://dx.doi.org/10.1371/journal.pone.0221132 |
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