Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive cellular changes to reestablish homeostasis. If stress resolution fails, the UPR commits the cell to apoptotic death. Here we show that in hematopoietic cells, including multiple myeloma (MM),...

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Detalles Bibliográficos
Autores principales: Shemorry, Anna, Harnoss, Jonathan M, Guttman, Ofer, Marsters, Scot A, Kőműves, László G, Lawrence, David A, Ashkenazi, Avi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711704/
https://www.ncbi.nlm.nih.gov/pubmed/31453810
http://dx.doi.org/10.7554/eLife.47084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711704/
https://www.ncbi.nlm.nih.gov/pubmed/31453810
http://dx.doi.org/10.7554/eLife.47084

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