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FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding

FcγRIIB binding to its ligand suppresses immune cell activation. A single-nucleotide polymorphic (SNP) change, I232T, in the transmembrane (TM) domain of FcγRIIB loses its suppressive function, which is clinically associated with systemic lupus erythematosus (SLE). Previously, we reported that I232T...

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Detalles Bibliográficos
Autores principales:	Hu, Wei, Zhang, Yong, Sun, Xiaolin, Zhang, Tongtong, Xu, Liling, Xie, Hengyi, Li, Zhanguo, Liu, Wanli, Lou, Jizhong, Chen, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711707/ https://www.ncbi.nlm.nih.gov/pubmed/31343409 http://dx.doi.org/10.7554/eLife.46689

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