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Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin
A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization by polyclonal human sera. The serum of some individua...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711711/ https://www.ncbi.nlm.nih.gov/pubmed/31452511 http://dx.doi.org/10.7554/eLife.49324 |