Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis

RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclear. Here we generated RAP1-deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs...

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Detalles Bibliográficos
Autores principales: Zhang, Xing, Liu, Zunpeng, Liu, Xiaoqian, Wang, Si, Zhang, Yiyuan, He, Xiaojuan, Sun, Shuhui, Ma, Shuai, Shyh-Chang, Ng, Liu, Feng, Wang, Qiang, Wang, Xiaoqun, Liu, Lin, Zhang, Weiqi, Song, Moshi, Liu, Guang-Hui, Qu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711945/
https://www.ncbi.nlm.nih.gov/pubmed/30796637
http://dx.doi.org/10.1007/s13238-019-0610-7

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