PIDD interaction with KEAP1 as a new mutation-independent mechanism to promote NRF2 stabilization and chemoresistance in NSCLC

Chemotherapy resistance is a major problem in non-small cell lung cancer (NSCLC) treatment. A major mechanism of chemoresistance involves stabilization of the NRF2 transcription factor. NRF2 levels are normally tightly regulated through interaction with KEAP1, an adaptor that targets NRF2 to the CUL...

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Detalles Bibliográficos
Autores principales: Ji, Lili, Zhang, Rui, Chen, Jie, Xue, Qun, Moghal, Nadeem, Tsao, Ming-Sound
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712044/
https://www.ncbi.nlm.nih.gov/pubmed/31455821
http://dx.doi.org/10.1038/s41598-019-48763-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712044/
https://www.ncbi.nlm.nih.gov/pubmed/31455821
http://dx.doi.org/10.1038/s41598-019-48763-4

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