Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes

Hypertrophic cardiomyopathy (HCM) is often caused by single sarcomeric gene mutations that affect muscle contraction. Pharmacological correction of mutation effects prevents but does not reverse disease in mouse models. Suspecting that diseased extracellular matrix is to blame, we obtained myocardiu...

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Detalles Bibliográficos
Autores principales: Sewanan, Lorenzo R., Schwan, Jonas, Kluger, Jonathan, Park, Jinkyu, Jacoby, Daniel L., Qyang, Yibing, Campbell, Stuart G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712054/
https://www.ncbi.nlm.nih.gov/pubmed/31468004
http://dx.doi.org/10.1016/j.jacbts.2019.03.004

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