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Modelling of substrate access and substrate binding to cephalosporin acylases

Semisynthetic cephalosporins are widely used antibiotics currently produced by different chemical steps under harsh conditions, which results in a considerable amount of toxic waste. Biocatalytic synthesis by the cephalosporin acylase from Pseudomonas sp. strain N176 is a promising alternative. Desp...

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Detalles Bibliográficos
Autores principales:	Ferrario, Valerio, Fischer, Mona, Zhu, Yushan, Pleiss, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712217/ https://www.ncbi.nlm.nih.gov/pubmed/31455800 http://dx.doi.org/10.1038/s41598-019-48849-z

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