The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis

Current treatment of cutaneous leishmaniasis includes pentavalent antimonials as first-line drugs, but this therapy has shown severe adverse effects. An alternative to minimize this issue is based on combination therapy scheme with other drugs. In this study we analyzed the potential of the associat...

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Detalles Bibliográficos
Autores principales: Gonçalves-Oliveira, Luiz Filipe, Souza-Silva, Franklin, de Castro Côrtes, Luzia Monteiro, Veloso, Laura Barral, Santini Pereira, Bernardo Acácio, Cysne-Finkelstein, Lea, Lechuga, Guilherme Curty, Bourguignon, Saulo Cabral, Almeida-Souza, Fernando, da Silva Calabrese, Kátia, Ferreira, Vitor Francisco, Alves, Carlos Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712286/
https://www.ncbi.nlm.nih.gov/pubmed/31430693
http://dx.doi.org/10.1016/j.ijpddr.2019.08.002

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