Cargando…

Neurobiological links between stress and anxiety

Stress and anxiety have intertwined behavioral and neural underpinnings. These commonalities are critical for understanding each state, as well as their mutual interactions. Grasping the mechanisms underlying this bidirectional relationship will have major clinical implications for managing a wide r...

Descripción completa

Detalles Bibliográficos
Autores principales: Daviu, Nuria, Bruchas, Michael R., Moghaddam, Bita, Sandi, Carmen, Beyeler, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712367/
https://www.ncbi.nlm.nih.gov/pubmed/31467945
http://dx.doi.org/10.1016/j.ynstr.2019.100191
_version_ 1783446665859956736
author Daviu, Nuria
Bruchas, Michael R.
Moghaddam, Bita
Sandi, Carmen
Beyeler, Anna
author_facet Daviu, Nuria
Bruchas, Michael R.
Moghaddam, Bita
Sandi, Carmen
Beyeler, Anna
author_sort Daviu, Nuria
collection PubMed
description Stress and anxiety have intertwined behavioral and neural underpinnings. These commonalities are critical for understanding each state, as well as their mutual interactions. Grasping the mechanisms underlying this bidirectional relationship will have major clinical implications for managing a wide range of psychopathologies. After briefly defining key concepts for the study of stress and anxiety in pre-clinical models, we present circuit, as well as cellular and molecular mechanisms involved in either or both stress and anxiety. First, we review studies on divergent circuits of the basolateral amygdala (BLA) underlying emotional valence processing and anxiety-like behaviors, and how norepinephrine inputs from the locus coeruleus (LC) to the BLA are responsible for acute-stress induced anxiety. We then describe recent studies revealing a new role for mitochondrial function within the nucleus accumbens (NAc), defining individual trait anxiety in rodents, and participating in the link between stress and anxiety. Next, we report findings on the impact of anxiety on reward encoding through alteration of circuit dynamic synchronicity. Finally, we present work unravelling a new role for hypothalamic corticotropin-releasing hormone (CRH) neurons in controlling anxiety-like and stress-induce behaviors. Altogether, the research reviewed here reveals circuits sharing subcortical nodes and underlying the processing of both stress and anxiety. Understanding the neural overlap between these two psychobiological states, might provide alternative strategies to manage disorders such as post-traumatic stress disorder (PTSD).
format Online
Article
Text
id pubmed-6712367
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-67123672019-08-29 Neurobiological links between stress and anxiety Daviu, Nuria Bruchas, Michael R. Moghaddam, Bita Sandi, Carmen Beyeler, Anna Neurobiol Stress Article from the Special Issue on Stress Neurobiology Workshop 2018; Edited by Lawrence Reagan,Richard Hunter and Matthew N. Hill Stress and anxiety have intertwined behavioral and neural underpinnings. These commonalities are critical for understanding each state, as well as their mutual interactions. Grasping the mechanisms underlying this bidirectional relationship will have major clinical implications for managing a wide range of psychopathologies. After briefly defining key concepts for the study of stress and anxiety in pre-clinical models, we present circuit, as well as cellular and molecular mechanisms involved in either or both stress and anxiety. First, we review studies on divergent circuits of the basolateral amygdala (BLA) underlying emotional valence processing and anxiety-like behaviors, and how norepinephrine inputs from the locus coeruleus (LC) to the BLA are responsible for acute-stress induced anxiety. We then describe recent studies revealing a new role for mitochondrial function within the nucleus accumbens (NAc), defining individual trait anxiety in rodents, and participating in the link between stress and anxiety. Next, we report findings on the impact of anxiety on reward encoding through alteration of circuit dynamic synchronicity. Finally, we present work unravelling a new role for hypothalamic corticotropin-releasing hormone (CRH) neurons in controlling anxiety-like and stress-induce behaviors. Altogether, the research reviewed here reveals circuits sharing subcortical nodes and underlying the processing of both stress and anxiety. Understanding the neural overlap between these two psychobiological states, might provide alternative strategies to manage disorders such as post-traumatic stress disorder (PTSD). Elsevier 2019-08-13 /pmc/articles/PMC6712367/ /pubmed/31467945 http://dx.doi.org/10.1016/j.ynstr.2019.100191 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article from the Special Issue on Stress Neurobiology Workshop 2018; Edited by Lawrence Reagan,Richard Hunter and Matthew N. Hill
Daviu, Nuria
Bruchas, Michael R.
Moghaddam, Bita
Sandi, Carmen
Beyeler, Anna
Neurobiological links between stress and anxiety
title Neurobiological links between stress and anxiety
title_full Neurobiological links between stress and anxiety
title_fullStr Neurobiological links between stress and anxiety
title_full_unstemmed Neurobiological links between stress and anxiety
title_short Neurobiological links between stress and anxiety
title_sort neurobiological links between stress and anxiety
topic Article from the Special Issue on Stress Neurobiology Workshop 2018; Edited by Lawrence Reagan,Richard Hunter and Matthew N. Hill
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712367/
https://www.ncbi.nlm.nih.gov/pubmed/31467945
http://dx.doi.org/10.1016/j.ynstr.2019.100191
work_keys_str_mv AT daviunuria neurobiologicallinksbetweenstressandanxiety
AT bruchasmichaelr neurobiologicallinksbetweenstressandanxiety
AT moghaddambita neurobiologicallinksbetweenstressandanxiety
AT sandicarmen neurobiologicallinksbetweenstressandanxiety
AT beyeleranna neurobiologicallinksbetweenstressandanxiety