Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant

Nullbasic is a mutant form of the HIV-1 transcriptional activator protein (Tat) that strongly inhibits HIV-1 transcription and replication in lymphocytes in vitro. To investigate Nullbasic inhibition in vivo, we employed an NSG mouse model where animals were engrafted with primary human CD4(+) cells...

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Detalles Bibliográficos
Autores principales: Jin, Hongping, Sun, Yifan, Li, Dongsheng, Lin, Min-Hsuan, Lor, Mary, Rustanti, Lina, Harrich, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712395/
https://www.ncbi.nlm.nih.gov/pubmed/31455650
http://dx.doi.org/10.1128/mBio.01769-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712395/
https://www.ncbi.nlm.nih.gov/pubmed/31455650
http://dx.doi.org/10.1128/mBio.01769-19

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