Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene

Here, we investigated the clinicopathological and mutation profiles of colorectal cancer (CRC) with POLE mutations. Whole‐exome sequencing was performed in 910 surgically resected primary CRCs. Tumors exceeding 500 counts of nonsynonymous single nucleotide variants (SNVs) were classified as hypermut...

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Detalles Bibliográficos
Autores principales: Hino, Hitoshi, Shiomi, Akio, Kusuhara, Masatoshi, Kagawa, Hiroyasu, Yamakawa, Yushi, Hatakeyama, Keiichi, Kawabata, Takanori, Oishi, Takuma, Urakami, Kenichi, Nagashima, Takeshi, Kinugasa, Yusuke, Yamaguchi, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712448/
https://www.ncbi.nlm.nih.gov/pubmed/31240875
http://dx.doi.org/10.1002/cam4.2344

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