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Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

Linc00152, located on chromosome 2p11.2, is a long intergenic non‐coding RNA molecule with 828 nucleotides that is highly expressed in many types of human tumor tissues, especially in malignant tumors of the digestive system. Linc00152 promotes the occurrence and development of tumors by increasing...

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Autores principales: Xu, Jiasheng, Guo, Jingjing, Jiang, Yangkai, Liu, Yujun, Liao, Kaili, Fu, Zhonghua, Xiong, Zhenfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712457/
https://www.ncbi.nlm.nih.gov/pubmed/31270960
http://dx.doi.org/10.1002/cam4.2245
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author Xu, Jiasheng
Guo, Jingjing
Jiang, Yangkai
Liu, Yujun
Liao, Kaili
Fu, Zhonghua
Xiong, Zhenfang
author_facet Xu, Jiasheng
Guo, Jingjing
Jiang, Yangkai
Liu, Yujun
Liao, Kaili
Fu, Zhonghua
Xiong, Zhenfang
author_sort Xu, Jiasheng
collection PubMed
description Linc00152, located on chromosome 2p11.2, is a long intergenic non‐coding RNA molecule with 828 nucleotides that is highly expressed in many types of human tumor tissues, especially in malignant tumors of the digestive system. Linc00152 promotes the occurrence and development of tumors by increasing tumor cell proliferation, invasion, metastasis, and apoptosis. Additionally, linc00152 contributes to the carcinogenesis of several cancers, including gastric cancer, liver cancer, hepatocellular carcinoma, gallbladder cancer, clear cell renal cell carcinoma, and colorectal cancer, by disturbing various signaling pathways (eg PI3K/AKT, mTOR, IL‐1, and NOTCH 1 signaling pathways). High linc00152 expression levels are associated with chemoresistance as well as poor prognosis and shorter survival. Continual advances made in the relevant research have indicated that linc00152 may be useful as a new tumor molecular biomarker, applicable for tumor diagnosis, targeted therapy, and prognosis assessment. This review summarizes the progress in the research into the relationship between linc00152 and the occurrence and development of malignancies based on molecular functions, regulatory mechanisms, and clinical applications.
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spelling pubmed-67124572019-09-04 Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies Xu, Jiasheng Guo, Jingjing Jiang, Yangkai Liu, Yujun Liao, Kaili Fu, Zhonghua Xiong, Zhenfang Cancer Med Cancer Biology Linc00152, located on chromosome 2p11.2, is a long intergenic non‐coding RNA molecule with 828 nucleotides that is highly expressed in many types of human tumor tissues, especially in malignant tumors of the digestive system. Linc00152 promotes the occurrence and development of tumors by increasing tumor cell proliferation, invasion, metastasis, and apoptosis. Additionally, linc00152 contributes to the carcinogenesis of several cancers, including gastric cancer, liver cancer, hepatocellular carcinoma, gallbladder cancer, clear cell renal cell carcinoma, and colorectal cancer, by disturbing various signaling pathways (eg PI3K/AKT, mTOR, IL‐1, and NOTCH 1 signaling pathways). High linc00152 expression levels are associated with chemoresistance as well as poor prognosis and shorter survival. Continual advances made in the relevant research have indicated that linc00152 may be useful as a new tumor molecular biomarker, applicable for tumor diagnosis, targeted therapy, and prognosis assessment. This review summarizes the progress in the research into the relationship between linc00152 and the occurrence and development of malignancies based on molecular functions, regulatory mechanisms, and clinical applications. John Wiley and Sons Inc. 2019-07-04 /pmc/articles/PMC6712457/ /pubmed/31270960 http://dx.doi.org/10.1002/cam4.2245 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Xu, Jiasheng
Guo, Jingjing
Jiang, Yangkai
Liu, Yujun
Liao, Kaili
Fu, Zhonghua
Xiong, Zhenfang
Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies
title Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies
title_full Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies
title_fullStr Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies
title_full_unstemmed Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies
title_short Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies
title_sort improved characterization of the relationship between long intergenic non‐coding rna linc00152 and the occurrence and development of malignancies
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712457/
https://www.ncbi.nlm.nih.gov/pubmed/31270960
http://dx.doi.org/10.1002/cam4.2245
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