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BET inhibitor JQ1 suppresses cell proliferation via inducing autophagy and activating LKB1/AMPK in bladder cancer cells

AIM: JQ1, a BET bromodomain inhibitor, is a promising therapeutic approach for bladder cancer (BC). Our study aimed to determine whether autophagy is induced by JQ1 and its potential role toward proliferation in BC. METHODS: Cell proliferation was determined by methylthiazolyldiphenyl‐tetrazolium br...

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Detalles Bibliográficos
Autores principales:	Li, Feng, Yang, Chao, Zhang, Hai‐Bao, Ma, Jianbin, Jia, Jing, Tang, Xiaoshuang, Zeng, Jin, Chong, Tie, Wang, Xinyang, He, Dalin, Guo, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712466/ https://www.ncbi.nlm.nih.gov/pubmed/31250978 http://dx.doi.org/10.1002/cam4.2385

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