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Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women

BACKGROUND: Although high‐risk human papillomavirus (HR‐HPV) infection is recognized as the main cause of cervical cancer, only a minority of HPV‐infected women develop this malignancy. Increasing evidence suggests that alterations of telomere length might be implicated in carcinogenesis. However, t...

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Autores principales: Chen, Xiaojun, Wei, Sun, Ma, Hongxia, Jin, Guangfu, Hu, Zhibin, Suping, Han, Li, Dake, Hang, Dong, Wu, Xiaohua, Li, Ni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712472/
https://www.ncbi.nlm.nih.gov/pubmed/31243901
http://dx.doi.org/10.1002/cam4.2246
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author Chen, Xiaojun
Wei, Sun
Ma, Hongxia
Jin, Guangfu
Hu, Zhibin
Suping, Han
Li, Dake
Hang, Dong
Wu, Xiaohua
Li, Ni
author_facet Chen, Xiaojun
Wei, Sun
Ma, Hongxia
Jin, Guangfu
Hu, Zhibin
Suping, Han
Li, Dake
Hang, Dong
Wu, Xiaohua
Li, Ni
author_sort Chen, Xiaojun
collection PubMed
description BACKGROUND: Although high‐risk human papillomavirus (HR‐HPV) infection is recognized as the main cause of cervical cancer, only a minority of HPV‐infected women develop this malignancy. Increasing evidence suggests that alterations of telomere length might be implicated in carcinogenesis. However, the association between cervical cancer and telomere length remains unknown. METHODS: This case‐control study included 591 cervical cancer patients and 373 cancer‐free controls, all of whom were infected with HR‐HPV. Relative telomere length (RTL) in cervical cancer exfoliated cells was measured by quantitative PCR. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression analysis. RESULTS: HPV16, 18, 52, and 58 were common in both case and control groups. The proportion of HPV16 infection tended to increase across the quartiles of RTL (P (trend) < 0.001). There was no statistically significant association of RTL with tumor differentiation, histological type, and FIGO stage. After adjustment for age and HPV types, the lowest quartile of RTL presented a 49% lower risk (OR = 0.51, 95% CI: 0.35, 0.76; P < 0.001) than those with the highest quartile of RTL. There was also a dose‐response relationship of shorter RTL on lower risk of cervical cancer (P (trend) < 0.001). CONCLUSION: Shortened telomere length in cervical exfoliated cells was related to the lower risk of cervical cancer among HR‐HPV‐positive women, which might help to improve cervical cancer screening and surveillance. Further prospective studies with large sample should be designed to validate our preliminary findings, and evaluate the potential efficacy of telomere length for cervical cancer screening.
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spelling pubmed-67124722019-09-04 Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women Chen, Xiaojun Wei, Sun Ma, Hongxia Jin, Guangfu Hu, Zhibin Suping, Han Li, Dake Hang, Dong Wu, Xiaohua Li, Ni Cancer Med Cancer Prevention BACKGROUND: Although high‐risk human papillomavirus (HR‐HPV) infection is recognized as the main cause of cervical cancer, only a minority of HPV‐infected women develop this malignancy. Increasing evidence suggests that alterations of telomere length might be implicated in carcinogenesis. However, the association between cervical cancer and telomere length remains unknown. METHODS: This case‐control study included 591 cervical cancer patients and 373 cancer‐free controls, all of whom were infected with HR‐HPV. Relative telomere length (RTL) in cervical cancer exfoliated cells was measured by quantitative PCR. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression analysis. RESULTS: HPV16, 18, 52, and 58 were common in both case and control groups. The proportion of HPV16 infection tended to increase across the quartiles of RTL (P (trend) < 0.001). There was no statistically significant association of RTL with tumor differentiation, histological type, and FIGO stage. After adjustment for age and HPV types, the lowest quartile of RTL presented a 49% lower risk (OR = 0.51, 95% CI: 0.35, 0.76; P < 0.001) than those with the highest quartile of RTL. There was also a dose‐response relationship of shorter RTL on lower risk of cervical cancer (P (trend) < 0.001). CONCLUSION: Shortened telomere length in cervical exfoliated cells was related to the lower risk of cervical cancer among HR‐HPV‐positive women, which might help to improve cervical cancer screening and surveillance. Further prospective studies with large sample should be designed to validate our preliminary findings, and evaluate the potential efficacy of telomere length for cervical cancer screening. John Wiley and Sons Inc. 2019-06-26 /pmc/articles/PMC6712472/ /pubmed/31243901 http://dx.doi.org/10.1002/cam4.2246 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Chen, Xiaojun
Wei, Sun
Ma, Hongxia
Jin, Guangfu
Hu, Zhibin
Suping, Han
Li, Dake
Hang, Dong
Wu, Xiaohua
Li, Ni
Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women
title Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women
title_full Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women
title_fullStr Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women
title_full_unstemmed Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women
title_short Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women
title_sort telomere length in cervical exfoliated cells, interaction with hpv genotype, and cervical cancer occurrence among high‐risk hpv‐positive women
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712472/
https://www.ncbi.nlm.nih.gov/pubmed/31243901
http://dx.doi.org/10.1002/cam4.2246
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