Cargando…

Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K‐Akt signaling in gastric cancer

BACKGROUND: As the most abundant epigenetic modification on mRNAs and long non‐coding RNAs, N6‐methyladenosine (m6A) modification extensively exists in mammalian cells. Controlled by writers (methyltransferases), readers (signal transducers), and erasers (demethylases), m6A influences mRNA structure...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Cheng, Zhang, Mengqi, Ge, Sai, Huang, Wenwen, Lin, Xiaoting, Gao, Jing, Gong, Jifang, Shen, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712480/ https://www.ncbi.nlm.nih.gov/pubmed/31243897 http://dx.doi.org/10.1002/cam4.2360

Ejemplares similares

YARS as an oncogenic protein that promotes gastric cancer progression through activating PI3K-Akt signaling
por: Zhang, Cheng, et al.
Publicado: (2020)

Angiotensin II enhances the proliferation of Natural Killer/T-cell lymphoma cells via activating PI3K/Akt signaling pathway
por: Zhang, Gui-Hua, et al.
Publicado: (2020)

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
por: Zhu, Haoran, et al.
Publicado: (2022)

MiR-27a-3p enhances the cisplatin sensitivity in hepatocellular carcinoma cells through inhibiting PI3K/Akt pathway
por: Yang, Ying, et al.
Publicado: (2021)

SKA3 promotes lung adenocarcinoma metastasis through the EGFR–PI3K–Akt axis
por: Hu, Dan-dan, et al.
Publicado: (2020)

LncRNA‐LOC101928316 contributes to gastric cancer progression through regulating PI3K‐Akt‐mTOR signaling pathway
por: Li, Chengyun, et al.
Publicado: (2019)

Apoptin‐derived peptide reverses cisplatin resistance in gastric cancer through the PI3K–AKT signaling pathway
por: Zhou, Danyang, et al.
Publicado: (2018)

MicroRNA‐4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non‐small cell lung cancer
por: Ling, Chunhua, et al.
Publicado: (2019)

Embryonic stem cell microenvironment suppresses the malignancy of cutaneous melanoma cells by down‐regulating PI3K/AKT pathway
por: Wang, Chenjie, et al.
Publicado: (2019)

Magnolol induces cell death through PI3K/Akt‐mediated epigenetic modifications boosting treatment of BRAF‐ and NRAS‐mutant melanoma
por: Emran, Abdullah Al, et al.
Publicado: (2019)

Digoxin exerts anticancer activity on human nonsmall cell lung cancer cells by blocking PI3K/Akt pathway
por: Wang, Yingying, et al.
Publicado: (2021)

AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K/Akt signaling pathway in gastric cancer
por: Liu, Xi, et al.
Publicado: (2016)

Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway
por: Huang, Yun, et al.
Publicado: (2020)

AKR1B10 regulates M2 macrophage polarization to promote the malignant phenotype of gastric cancer
por: Wu, Yi, et al.
Publicado: (2023)

Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway
por: Xu, Yonggang, et al.
Publicado: (2021)

LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways
por: Liu, Zhihui, et al.
Publicado: (2020)

NLRP3 augmented resistance to gemcitabine in triple-negative breast cancer cells via EMT/IL-1β/Wnt/β-catenin signaling pathway
por: Zheng, Qiao, et al.
Publicado: (2020)

MiR-25-3p targets PTEN to regulate the migration, invasion, and apoptosis of esophageal cancer cells via the PI3K/AKT pathway
por: Zhang, Liang, et al.
Publicado: (2020)

LncRNA UCA1 elevates the resistance of human leukemia cells to daunorubicin by the PI3K/AKT pathway via sponging miR-613
por: Yao, Qiying, et al.
Publicado: (2021)

Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway
por: Cai, Fangzhen, et al.
Publicado: (2020)

ARHGAP42 promotes cell migration and invasion involving PI3K/Akt signaling pathway in nasopharyngeal carcinoma
por: Hu, Qian, et al.
Publicado: (2018)

Clinical significance of phenotyping and karyotyping of circulating tumor cells in patients with advanced gastric cancer
por: Li, Yilin, et al.
Publicado: (2014)

Erianin suppresses hepatocellular carcinoma cells through down-regulation of PI3K/AKT, p38 and ERK MAPK signaling pathways
por: Yang, Liang, et al.
Publicado: (2020)

WNT signaling and cancer stemness
por: Katoh, Masuko, et al.
Publicado: (2022)

miR‐107 regulates growth and metastasis of gastric cancer cells via activation of the PI3K‐AKT signaling pathway by down‐regulating FAT4
por: Wang, Li, et al.
Publicado: (2019)

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells
por: Hunter, Jill E., et al.
Publicado: (2022)

The multidrug resistance can be reversed for the decrease of P-gp and LRP by inhibiting PI3K/Akt/NF-κB signal pathway in nasopharynx carcinoma
por: Liu, Jin, et al.
Publicado: (2020)

Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers
por: Hong, Xuehui, et al.
Publicado: (2018)

Selenoprotein M stimulates the proliferative and metastatic capacities of renal cell carcinoma through activating the PI3K/AKT/mTOR pathway
por: Jiang, Hao, et al.
Publicado: (2019)

LncRNA HAND2-AS1 inhibits proliferation and promotes apoptosis of non-small cell lung cancer cells by inactivating PI3K/Akt pathway
por: Gao, Ting, et al.
Publicado: (2020)

Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway
por: Ying, Jun, et al.
Publicado: (2022)

SMG‐1 inhibition by miR‐192/‐215 causes epithelial‐mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling
por: Zhang, Xiaojing, et al.
Publicado: (2017)

SLC39A7, regulated by miR-139-5p, induces cell proliferation, migration and inhibits apoptosis in gastric cancer via Akt/mTOR signaling pathway
por: Zhang, Yanting, et al.
Publicado: (2020)

Wnt/β-catenin signaling as an emerging potential key pharmacological target in cholangiocarcinoma
por: Zhang, Guo-Feng, et al.
Publicado: (2020)

The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer
por: Routledge, Daniel, et al.
Publicado: (2022)

PI3K/AKT pathway regulates E-cadherin and Desmoglein 2 in aggressive prostate cancer
por: Barber, Alison G, et al.
Publicado: (2015)

MiR-940 promotes malignant progression of breast cancer by regulating FOXO3
por: Zhang, Huayao, et al.
Publicado: (2020)

Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway
por: Zhou, Wenjing, et al.
Publicado: (2018)

Puerarin 6″‐O‐xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/mTOR
por: Li, Long, et al.
Publicado: (2020)

The impact of a prior malignancy on outcomes in gastric cancer patients
por: Bian, Xiaoyuan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mcinvoc8cep6k3gthelpdj3msg