Sensitization of Tumors for Attack by Virus-Specific CD8+ T-Cells Through Antibody-Mediated Delivery of Immunogenic T-Cell Epitopes

Anti-tumor immunity is limited by a number of factors including the lack of fully activated T-cells, insufficient antigenic stimulation and the immune-suppressive tumor microenvironment. We addressed these hurdles by developing a novel class of immunoconjugates, Antibody-Targeted Pathogen-derived Pe...

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Detalles Bibliográficos
Autores principales: Sefrin, Julian P., Hillringhaus, Lars, Mundigl, Olaf, Mann, Karin, Ziegler-Landesberger, Doris, Seul, Heike, Tabares, Gloria, Knoblauch, Dominic, Leinenbach, Andreas, Friligou, Irene, Dziadek, Sebastian, Offringa, Rienk, Lifke, Valeria, Lifke, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712545/
https://www.ncbi.nlm.nih.gov/pubmed/31555260
http://dx.doi.org/10.3389/fimmu.2019.01962

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